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SCHEMBL30367373

SCHEMBL30367373

CC(C)C(=O)N1CCC(c2cc(-c3ccc(NC(=O)c4cccn(-c5ccc(F)cn5)c4=O)cc3)c3c(N)nn(C)c3c2)CC1

nearest known ligand 0.47

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
▸ TYRO3 Q06418 12/20 0.47
▸ MERTK Q12866 10/20 0.47
▸ AXL P30530 3/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30367626 0.91 TYRO3 (0.55) TYRO3MERTKAXL
SCHEMBL29052459 0.91 TYRO3 (0.55) TYRO3MERTKAXL
SCHEMBL29052469 0.91 MERTK (0.52) TYRO3MERTKAXL
SCHEMBL30367209 0.91 MERTK (0.52) TYRO3MERTKAXL
SCHEMBL29052440 0.85 TYRO3 (0.51) TYRO3MERTK
SCHEMBL30499560 0.84 TYRO3 (0.36) TYRO3MERTKAXL
SCHEMBL30367687 0.82 MET (0.51) TYRO3MERTKAXL
SCHEMBL29052490 0.82 MET (0.51) TYRO3MERTKAXL
SCHEMBL30367688 0.82 MERTK (0.46) TYRO3MERTKAXL
SCHEMBL29052756 0.82 MERTK (0.46) TYRO3MERTKAXL

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023155886-A1 PYRAZOLOPYRIDINE COMPOUNDS AS TAM INHIBITORS SHANGHAI ANTENGENE CORPORATION LIMITED (CN) 2023-08-24 — — WO disclosed
CN-116437918-A Pyrazolopyridine compounds as TAM inhibitors 上海德琪医药科技有限公司 2023-07-14 — — CN disclosed
WO-2023051464-A1 PYRAZOLOPYRIDINE COMPOUNDS AS TAM INHIBITORS SHANGHAI ANTENGENE CORPORATION LIMITED (CN) 2023-04-06 — — WO disclosed