Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPO | P05164 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | PDE2A | O00408 | 5/20 | 0.31 |
| ▸ | PDE10A | Q9Y233 | 5/20 | 0.31 |
| ▸ | MAOA | P21397 | 2/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | HBB | P68871 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28974954 | 1.00 | MPO (0.34) | MPONPSR1KDM4EGAAL3MBTL1 | |
| SCHEMBL23887808 | 0.85 | MPO (0.47) | MPONPSR1KDM4EGAAL3MBTL1 | |
| SCHEMBL23887697 | 0.78 | DYRK1A (0.39) | PDE10AMAOADYRK1A | |
| SCHEMBL25544331 | 0.76 | ALDH1A1 (0.39) | NPSR1KDM4EMAPTKMT2AALDH1A1 | |
| SCHEMBL23887701 | 0.74 | TRPV1 (0.37) | MPOKDM4EGAAMAPTKMT2A | |
| SCHEMBL30120959 | 0.74 | TRPV1 (0.37) | MPOKDM4EGAAMAPTKMT2A | |
| SCHEMBL7125134 | 0.70 | MAOA (0.53) | MPOKDM4EMAPTALDH1A1HPGD | |
| SCHEMBL23896011 | 0.69 | MPO (0.47) | MPONPSR1KDM4EGAAL3MBTL1 | |
| SCHEMBL28298305 | 0.65 | FFAR1 (0.37) | KDM4EL3MBTL1KMT2AMAOALMNA | |
| SCHEMBL23832432 | 0.64 | CYP2A6 (0.45) | KDM4EMAPTMAPK1KMT2ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115697969-A | 7-or 8-hydroxy-isoquinoline and 7-or 8-hydroxy-quinoline derivatives as alpha-1 antitrypsin modulators for the treatment of alpha-1 antitrypsin deficiency (AATD) | 弗特克斯药品有限公司 | 2023-02-03 | — | — | CN | disclosed |