Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 11/20 | 0.41 |
| ▸ | KHK | P50053 | 1/20 | 0.36 |
| ▸ | QDPR | P09417 | 2/20 | 0.35 |
| ▸ | CCR1 | P32246 | 1/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
| ▸ | BTK | Q06187 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30367031 | 0.89 | NAMPT (0.43) | NAMPTKHKQDPRCCR1CNR1 | |
| SCHEMBL30367296 | 0.79 | MAPK1 (0.39) | NAMPTCCR1BTK | |
| SCHEMBL30367298 | 0.72 | NAMPT (0.48) | NAMPTQDPRCCR1KCNH2HRH3 | |
| SCHEMBL30367241 | 0.70 | NAMPT (0.43) | NAMPTQDPRCCR1KCNH2HRH3 | |
| SCHEMBL29052499 | 0.70 | NAMPT (0.40) | NAMPTQDPRBTK | |
| SCHEMBL30367401 | 0.69 | NAMPT (0.36) | NAMPT | |
| SCHEMBL30585453 | 0.68 | LYN (0.43) | NAMPT | |
| SCHEMBL30367181 | 0.68 | LMNA (0.37) | — | |
| SCHEMBL14197130 | 0.68 | NAMPT (0.58) | NAMPTQDPRCCR1KCNH2HRH3 | |
| SCHEMBL30367384 | 0.67 | MAPK1 (0.40) | NAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023155886-A1 | PYRAZOLOPYRIDINE COMPOUNDS AS TAM INHIBITORS | SHANGHAI ANTENGENE CORPORATION LIMITED (CN) | 2023-08-24 | — | — | WO | disclosed |
| CN-116437918-A | Pyrazolopyridine compounds as TAM inhibitors | 上海德琪医药科技有限公司 | 2023-07-14 | — | — | CN | disclosed |
| WO-2023051464-A1 | PYRAZOLOPYRIDINE COMPOUNDS AS TAM INHIBITORS | SHANGHAI ANTENGENE CORPORATION LIMITED (CN) | 2023-04-06 | — | — | WO | disclosed |