Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 8/20 | 0.46 |
| ▸ | ADAM10 | O14672 | 2/20 | 0.38 |
| ▸ | MMP2 | P08253 | 2/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | MMP3 | P08254 | 1/20 | 0.38 |
| ▸ | CCR1 | P32246 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.35 |
| ▸ | QDPR | P09417 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30367315 | 0.80 | NAMPT (0.45) | NAMPTKCNH2HRH3CCR1KDM4E | |
| SCHEMBL30367298 | 0.71 | NAMPT (0.48) | NAMPTADAM10MMP2KCNH2HRH3 | |
| SCHEMBL30366906 | 0.70 | NAMPT (0.45) | NAMPTCCR1MAPTALDH1A1QDPR | |
| SCHEMBL27694889 | 0.70 | NAMPT (0.55) | NAMPTKCNH2HRH3CCR1ALDH1A1 | |
| SCHEMBL29052438 | 0.68 | NAMPT (0.43) | NAMPTKCNH2HRH3CCR1KDM4E | |
| SCHEMBL14197130 | 0.68 | NAMPT (0.58) | NAMPTKCNH2HRH3CCR1MAPT | |
| SCHEMBL3696698 | 0.64 | NAMPT (1.00) | NAMPT | |
| SCHEMBL1366521 | 0.62 | ADAM10 (0.56) | NAMPTADAM10MMP2KCNH2HRH3 | |
| SCHEMBL2176823 | 0.62 | NAMPT (0.49) | NAMPTADAM10MMP2MMP3 | |
| SCHEMBL13925377 | 0.62 | NAMPT (0.47) | NAMPTKCNH2HRH3CCR1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023051464-A1 | PYRAZOLOPYRIDINE COMPOUNDS AS TAM INHIBITORS | SHANGHAI ANTENGENE CORPORATION LIMITED (CN) | 2023-04-06 | — | — | WO | disclosed |