Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 4/20 | 0.55 |
| ▸ | TYK2 | P29597 | 4/20 | 0.55 |
| ▸ | JAK1 | P23458 | 3/20 | 0.55 |
| ▸ | ANO1 | Q5XXA6 | 5/20 | 0.53 |
| ▸ | CSF1R | P07333 | 1/20 | 0.53 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.53 |
| ▸ | KIT | P10721 | 1/20 | 0.53 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.53 |
| ▸ | FLT3 | P36888 | 1/20 | 0.53 |
| ▸ | P2RX7 | Q99572 | 8/20 | 0.49 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.48 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.48 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30368259 | 0.89 | ANO1 (0.66) | JAK2TYK2JAK1ANO1CSF1R | |
| SCHEMBL30368210 | 0.86 | ANO1 (0.65) | JAK2TYK2JAK1ANO1 | |
| SCHEMBL30368170 | 0.82 | ANO1 (0.51) | JAK2TYK2JAK1ANO1CSF1R | |
| SCHEMBL30368230 | 0.81 | JAK2 (0.62) | JAK2TYK2JAK1ANO1KCNJ5 | |
| SCHEMBL30368144 | 0.81 | TYK2 (0.56) | TYK2ANO1P2RX7KCNJ5KCNJ3 | |
| SCHEMBL2717733 | 0.80 | GRK2 (0.55) | JAK2TYK2JAK1P2RX7 | |
| SCHEMBL25372122 | 0.78 | P2RX4 (0.61) | ANO1P2RX7KCNJ5KCNJ3ACKR3 | |
| SCHEMBL25375429 | 0.78 | P2RX4 (0.56) | ANO1P2RX7KCNJ5KCNJ3ACKR3 | |
| SCHEMBL30368345 | 0.78 | JAK2 (0.52) | JAK2TYK2JAK1ANO1 | |
| SCHEMBL30368445 | 0.78 | NTRK1 (0.51) | JAK2TYK2JAK1ANO1CSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4172146-A1 | SUBSTITUTED N-PHENYLACETAMIDES HAVING P2X4 RECEPTOR ANTAGONISTIC ACTIVITY | Bayer Aktiengesellschaft (DE) | 2023-05-03 | — | — | EP | disclosed |