Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADCY1 | Q08828 | 1/20 | 0.44 |
| ▸ | SRPK1 | Q96SB4 | 1/20 | 0.41 |
| ▸ | TEAD1 | P28347 | 2/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.40 |
| ▸ | CCR2 | P41597 | 4/20 | 0.40 |
| ▸ | PHGDH | O43175 | 2/20 | 0.40 |
| ▸ | DRD4 | P21917 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30370293 | 0.84 | HDAC1 (0.54) | TEAD1EPHX2KCNH2USP30 | |
| SCHEMBL25305452 | 0.81 | ADCY1 (0.43) | ADCY1SRPK1ALDH1A1 | |
| SCHEMBL24073585 | 0.80 | HDAC4 (0.46) | ADCY1 | |
| SCHEMBL25304821 | 0.78 | CTSL (0.42) | ADCY1SRPK1ALDH1A1 | |
| SCHEMBL24073569 | 0.78 | CTSL (0.41) | ADCY1SRPK1ALDH1A1USP30 | |
| SCHEMBL24073674 | 0.78 | CTSL (0.41) | ADCY1SRPK1ALDH1A1USP30 | |
| SCHEMBL24073683 | 0.78 | CTSL (0.41) | ADCY1SRPK1ALDH1A1USP30 | |
| SCHEMBL25304504 | 0.77 | ADCY1 (0.43) | ADCY1ALDH1A1 | |
| Trifluoroacetic Acid SCHEMBL30370356 | 0.76 | ADCY1 (0.43) | ADCY1SRPK1ALDH1A1 | |
| SCHEMBL24073568 | 0.74 | CTSL (0.40) | ADCY1SRPK1USP30 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4157834-A1 | N-(1-CYANO-PYRROLIDIN-3-YL)-5-(3-(TRIFLUOROMETHYL)PHENYL)OXAZOLE-2-CARBOXAMIDE DERIVATIVES AND THE CORRESPONDING OXADIAZOLE DERIVATIVES AS USP30 INHIBITORS FOR THE TREATMENT OF MITOCHONDRIAL DYSFUNCTION | Mission Therapeutics Limited (GB) | 2023-04-05 | — | — | EP | disclosed |