Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTK6 | Q13882 | 4/20 | 0.41 |
| ▸ | LCK | P06239 | 1/20 | 0.38 |
| ▸ | EPHA2 | P29317 | 3/20 | 0.36 |
| ▸ | EPHB4 | P54760 | 3/20 | 0.36 |
| ▸ | KDR | P35968 | 2/20 | 0.36 |
| ▸ | SUV39H2 | Q9H5I1 | 4/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.34 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.34 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.34 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | GALR2 | O43603 | 1/20 | 0.34 |
| ▸ | GALR1 | P47211 | 1/20 | 0.34 |
| ▸ | BRAF | P15056 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | JAK3 | P52333 | 1/20 | 0.33 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.33 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28982185 | 0.92 | PTK6 (0.39) | PTK6LCKNR1H2NR1H3JAK2 | |
| SCHEMBL22123240 | 0.89 | PTK6 (0.50) | PTK6LCK | |
| SCHEMBL30171783 | 0.89 | PTK6 (0.50) | PTK6LCK | |
| SCHEMBL22123871 | 0.86 | PTK6 (0.40) | PTK6LCKEPHA2EPHB4KDR | |
| Trifluoroacetic Acid SCHEMBL30386113 | 0.86 | PTK6 (0.39) | PTK6LCKERBB2BRAF | |
| SCHEMBL25173551 | 0.84 | GPR119 (0.38) | PTK6ERBB2JAK2JAK3PTK2 | |
| SCHEMBL22123869 | 0.84 | EGFR (0.37) | PTK6LCKEPHA2EPHB4KDR | |
| SCHEMBL25176394 | 0.84 | PTK6 (0.39) | PTK6LCKMAPTNR1H2NR1H3 | |
| SCHEMBL30386338 | 0.83 | PTK6 (0.48) | PTK6LCK | |
| SCHEMBL25173466 | 0.82 | PTK6 (0.43) | PTK6GALR2GALR1JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4161931-A1 | NOVEL IMIDAZOPYRAZINE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2023-04-12 | — | — | EP | disclosed |