Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 5/20 | 0.37 |
| ▸ | PTK6 | Q13882 | 2/20 | 0.37 |
| ▸ | ALK | Q9UM73 | 4/20 | 0.36 |
| ▸ | KDR | P35968 | 5/20 | 0.36 |
| ▸ | EPHA2 | P29317 | 2/20 | 0.36 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.36 |
| ▸ | KMT5A | Q9NQR1 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | SUV39H2 | Q9H5I1 | 2/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
| ▸ | LCK | P06239 | 1/20 | 0.34 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22123871 | 0.91 | PTK6 (0.40) | EGFRPTK6KDREPHA2EPHB4 | |
| SCHEMBL30385489 | 0.84 | PTK6 (0.41) | PTK6ALKKDREPHA2EPHB4 | |
| SCHEMBL22156708 | 0.81 | EGFR (0.38) | EGFRPTK6ALKLCK | |
| SCHEMBL22124312 | 0.81 | BRD4 (0.41) | EGFRKDR | |
| SCHEMBL22123217 | 0.80 | PTK6 (0.48) | EGFRPTK6LCKERBB2 | |
| SCHEMBL25173466 | 0.80 | PTK6 (0.43) | PTK6 | |
| SCHEMBL25170927 | 0.79 | TGM2 (0.43) | PTK6KDREPHA2EPHB4 | |
| SCHEMBL22123805 | 0.78 | SYK (0.34) | EGFRPTK6KDR | |
| SCHEMBL25447130 | 0.78 | BRD4 (0.38) | EGFRPTK6SUV39H2 | |
| SCHEMBL22125440 | 0.77 | PTK6 (0.59) | PTK6LCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3898631-A1 | NOVEL IMIDAZOPYRAZINE DERIVATIVES AS ANTIBACTERIALS | F. Hoffmann-La Roche AG (CH) | 2021-10-27 | — | — | EP | disclosed |
| EP-3898629-A1 | IMIDAZOPYRAZINE DERIVATIVES AS ANTIBACTERIALS | F. Hoffmann-La Roche AG (CH) | 2021-10-27 | — | — | EP | disclosed |
| WO-2020126953-A1 | NOVEL IMIDAZOPYRAZINE DERIVATIVES AS ANTIBACTERIALS | F. HOFFMANN-LA ROCHE AG (CH) | 2020-06-25 | — | — | WO | disclosed |
| WO-2020127075-A1 | IMIDAZOPYRAZINE DERIVATIVES AS ANTIBACTERIALS | F. HOFFMANN-LA ROCHE AG (CH) | 2020-06-25 | — | — | WO | disclosed |