SCHEMBL3038818

SCHEMBL3038818

Nc1ccn([C@@]2(F)C[C@H](O)[C@@H](CO)O2)c(=O)n1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PDE3A Q14432 3/20 0.52
PDE4D Q08499 1/20 0.52
SLC29A1 Q99808 1/20 0.52
LMNA P02545 5/20 0.46
MTOR P42345 2/20 0.46
THRB P10828 1/20 0.46
MDM2 Q00987 1/20 0.46
NCOA1 Q15788 1/20 0.46
NCOA3 Q9Y6Q9 1/20 0.46
CACNA1F O60840 2/20 0.40
ALB P02768 2/20 0.40
MAPT P10636 2/20 0.40
CACNA1D Q01668 2/20 0.40
CACNA1S Q13698 2/20 0.40
CACNA1C Q13936 2/20 0.40
SMN1; SMN2 Q16637 2/20 0.36
POLB P06746 2/20 0.36
ALDH1A1 P00352 2/20 0.36
DNMT1 P26358 2/20 0.35
ADRB1 P08588 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3424602 0.84 PDE3A (0.47) PDE3APDE4DSLC29A1LMNAMTOR
SCHEMBL1939478 0.84 PDE3A (0.47) PDE3APDE4DSLC29A1LMNAMTOR
SCHEMBL28379714 0.84 PDE3A (0.47) PDE3APDE4DSLC29A1LMNAMTOR
SCHEMBL31448322 0.84 POLB (0.46) PDE3APDE4DSLC29A1POLBPOLA1
SCHEMBL3489429 0.84 PDE3A (0.47) PDE3APDE4DSLC29A1LMNAMTOR
SCHEMBL7794942 0.83 PDE3A (0.46) PDE3APDE4DSLC29A1LMNAMTOR
SCHEMBL4971926 0.83 PDE3A (0.46) PDE3APDE4DSLC29A1LMNAMTOR
SCHEMBL3449198 0.83 PDE3A (0.46) PDE3APDE4DSLC29A1LMNAMTOR
SCHEMBL51650 0.83 PDE3A (0.46) PDE3APDE4DSLC29A1LMNAMTOR
SCHEMBL992472 0.83 PDE3A (0.46) PDE3APDE4DSLC29A1LMNAMTOR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 175 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117070491-B Purine nucleoside phosphorylase mutant and preparation method of 2' -fluoronucleoside 吉林凯莱英制药有限公司 2024-01-19 CN claimed
CN-117106744-A Pyrimidine nucleoside phosphorylase mutant and preparation method of 2' -fluoronucleoside 吉林凯莱英制药有限公司 2023-11-24 CN claimed
CN-117070491-A Purine nucleoside phosphorylase mutant and preparation method of 2' -fluoronucleoside 吉林凯莱英制药有限公司 2023-11-17 CN claimed
CN-110234319-A The composition and its application method of benzamide and reactive compound 转化药物开发有限责任公司 2019-09-13 CN claimed
CN-105874059-A Improved methods for producing mammalian pluripotent stem cell-derived endodermal cells 宝生物欧洲公司 2016-08-17 CN claimed
CN-101868254-B Positron emission tomography probes for imaging immune activation and selected cancers UNIV CALIFORNIA 2013-08-21 CN claimed
CN-101868254-A The positron emission transaxial tomography probe that immune activation and selected cancers imaging are used UNIV CALIFORNIA 2010-10-20 CN claimed
CN-101312737-A Parapoxviruses in combination with traditional cytotoxic chemotherapeutic agents as biochemical treatments for cancer AICURIS GMBH & CO KG (DE) 2008-11-26 CN claimed
EP-1156827-A2 TREATMENT OF NEOPLASTIC DISEASES BY RADIATION Halogenetics, Inc. (US) 2001-11-28 EP claimed
WO-2000051639-A9 TREATMENT OF NEOPLASTIC DISEASES BY RADIATION HALOGENETICS INC (US) 2001-10-25 WO claimed
WO-2000051639-A2 TREATMENT OF NEOPLASTIC DISEASES BY RADIATION HALOGENETICS, INC. (US) 2000-09-08 WO claimed
EP-0504279-B1 FERMENTATION PROCESS FOR THE PRODUCTION OF PYRIMIDINE DEOXYRIBONUCLEOSIDES CHEMGEN CORP (US) 1997-07-09 EP claimed
US-5213972-A Production of thymidine and deoxyuridine, intermediates for AZT CHEMGEN CORPORATION (US) 1993-05-25 US claimed
EP-0504279-A4 FERMENTATION PROCESS FOR THE PRODUCTION OF PYRIMIDINE DEOXYRIBONUCLEOSIDES 1993-02-17 EP claimed
EP-0504279-A1 FERMENTATION PROCESS FOR THE PRODUCTION OF PYRIMIDINE DEOXYRIBONUCLEOSIDES. CHEMGEN CORP (US) 1992-09-23 EP claimed
WO-1991009130-A1 FERMENTATION PROCESS FOR THE PRODUCTION OF PYRIMIDINE DEOXYRIBONUCLEOSIDES CHEMGEN CORPORATION (US) 1991-06-27 WO claimed
EP-0287128-A1 Antitumor agent RESEARCH CORPORATION TECHNOLOGIES, INC. (US) 1988-10-19 EP claimed
CN-113396219-B Purification of mRNA by tangential flow filtration ETHRIS GMBH (DE) 2026-05-26 CN disclosed
WO-1991009130-A1 FERMENTATION PROCESS FOR THE PRODUCTION OF PYRIMIDINE DEOXYRIBONUCLEOSIDES CHEMGEN CORPORATION (US) 1991-06-27 WO disclosed
EP-0287128-A1 Antitumor agent RESEARCH CORPORATION TECHNOLOGIES, INC. (US) 1988-10-19 EP disclosed