Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.33 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.32 |
| ▸ | IDO1 | P14902 | 2/20 | 0.32 |
| ▸ | PARP1 | P09874 | 1/20 | 0.31 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.30 |
| ▸ | PTGES | O14684 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22075150 | 1.00 | ADORA3 (0.33) | ADORA3FGFR3KDRMAPK14IDO1 | |
| SCHEMBL22075259 | 0.88 | MAPT (0.36) | TGFBR1 | |
| SCHEMBL23416635 | 0.85 | TGFBR1 (0.32) | MAPK14TGFBR1 | |
| SCHEMBL26003698 | 0.83 | — | — | |
| SCHEMBL22075061 | 0.83 | TNIK (0.41) | MAPK14IDO1TGFBR1 | |
| SCHEMBL22075155 | 0.82 | ACVR1 (0.35) | FGFR3KDRMAPK14TGFBR1 | |
| SCHEMBL22075285 | 0.82 | TGFBR1 (0.43) | MAPK14IDO1TGFBR1 | |
| SCHEMBL22075263 | 0.81 | IDO1 (0.51) | ADORA3FGFR3KDRIDO1TGFBR1 | |
| SCHEMBL22075322 | 0.80 | HTR6 (0.40) | — | |
| SCHEMBL22074959 | 0.78 | ADORA3 (0.33) | ADORA3FGFR3KDRTGFBR1PTGES |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4165041-A1 | NAPHTHYRIDINE DERIVATIVES USEFUL AS ALK5 INHIBITORS | Theravance Biopharma R&D IP, LLC (US) | 2023-04-19 | — | — | EP | disclosed |