Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | KDM5A | P29375 | 1/20 | 0.46 |
| ▸ | JMJD1C | Q15652 | 1/20 | 0.46 |
| ▸ | KDM3A | Q9Y4C1 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | LOX | P28300 | 1/20 | 0.39 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.39 |
| ▸ | HTR3A | P46098 | 1/20 | 0.39 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.38 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.38 |
| ▸ | SYK | P43405 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25205112 | 1.00 | KDM4E (0.46) | KDM4EKDM5AJMJD1CKDM3AMEN1 | |
| SCHEMBL3265737 | 0.82 | HTR3A (0.39) | MEN1KMT2ALOXLOXL2HTR3A | |
| Bromide SCHEMBL28439102 | 0.80 | HTR3A (0.39) | MEN1KMT2ALOXLOXL2HTR3A | |
| SCHEMBL24128098 | 0.78 | CYP1A2 (0.38) | MEN1KMT2ALOXLOXL2HTR3A | |
| SCHEMBL30421382 | 0.78 | CYP1A2 (0.64) | KDM4EMEN1KMT2AGAAMTNR1A | |
| SCHEMBL12411165 | 0.77 | MAPK8 (0.49) | MEN1KMT2AHTR3AGRM4CYP1A2 | |
| SCHEMBL28860465 | 0.77 | MKNK1 (0.42) | GAAL3MBTL1LOXLOXL2HTR3A | |
| SCHEMBL10055017 | 0.76 | CLK4 (0.52) | — | |
| SCHEMBL28051845 | 0.76 | MTNR1A (0.38) | MEN1KMT2AHTR3AMTNR1AMTNR1B | |
| SCHEMBL28106387 | 0.76 | MTNR1A (0.38) | MEN1KMT2ALOXLOXL2HTR3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023091726-A1 | INHIBITORS OF CYCLIN‑DEPENDENT KINASE 12 (CDK12) | SYROS PHARMACEUTICALS, INC. (US) | 2023-05-25 | — | — | WO | disclosed |