Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 10/20 | 0.46 |
| ▸ | ULK1 | O75385 | 1/20 | 0.42 |
| ▸ | MAPK3 | P27361 | 4/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.40 |
| ▸ | TTK | P33981 | 1/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30397019 | 0.94 | ULK1 (0.43) | LRRK2ULK1MAPK3PTK2HSD11B1 | |
| SCHEMBL30397130 | 0.84 | MAPK3 (0.46) | LRRK2ULK1MAPK3EPHX2PTK2 | |
| SCHEMBL30397992 | 0.84 | MAPK3 (0.46) | LRRK2ULK1MAPK3EPHX2PTK2 | |
| SCHEMBL25531402 | 0.82 | ULK1 (0.49) | ULK1MAPK3HSD11B1CDK2KDR | |
| SCHEMBL30397492 | 0.82 | ULK1 (0.49) | ULK1MAPK3HSD11B1CDK2KDR | |
| SCHEMBL30397617 | 0.79 | ULK1 (0.46) | ULK1MAPK3PTK2HSD11B1CDK2 | |
| SCHEMBL25516689 | 0.79 | ULK1 (0.46) | ULK1MAPK3PTK2HSD11B1CDK2 | |
| SCHEMBL25522696 | 0.79 | ULK1 (0.55) | ULK1MAPK3PTK2CDK2KDR | |
| SCHEMBL25418820 | 0.79 | MAPK3 (0.37) | LRRK2ULK1MAPK3PTK2CDK2 | |
| SCHEMBL25524694 | 0.79 | MAPK3 (0.37) | LRRK2ULK1MAPK3PTK2CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023091726-A1 | INHIBITORS OF CYCLIN‑DEPENDENT KINASE 12 (CDK12) | SYROS PHARMACEUTICALS, INC. (US) | 2023-05-25 | — | — | WO | disclosed |