Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK3 | P27361 | 3/20 | 0.46 |
| ▸ | ULK1 | O75385 | 1/20 | 0.44 |
| ▸ | CDK2 | P24941 | 7/20 | 0.43 |
| ▸ | CCNE1 | P24864 | 6/20 | 0.43 |
| ▸ | CCNK | O75909 | 5/20 | 0.43 |
| ▸ | CDK12 | Q9NYV4 | 5/20 | 0.43 |
| ▸ | CCNT1 | O60563 | 4/20 | 0.43 |
| ▸ | CDK9 | P50750 | 4/20 | 0.43 |
| ▸ | CDK7 | P50613 | 2/20 | 0.43 |
| ▸ | CCNH | P51946 | 2/20 | 0.43 |
| ▸ | MNAT1 | P51948 | 2/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.40 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.38 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30397130 | 1.00 | MAPK3 (0.46) | MAPK3ULK1CDK2CCNE1CCNK | |
| SCHEMBL30397019 | 0.85 | ULK1 (0.43) | MAPK3ULK1CDK2CCNE1CCNK | |
| SCHEMBL30397381 | 0.84 | LRRK2 (0.46) | MAPK3ULK1CDK2KDREPHX2 | |
| SCHEMBL30397492 | 0.84 | ULK1 (0.49) | MAPK3ULK1CDK2CCNE1CCNK | |
| SCHEMBL25531402 | 0.84 | ULK1 (0.49) | MAPK3ULK1CDK2CCNE1CCNK | |
| SCHEMBL30397617 | 0.82 | ULK1 (0.46) | MAPK3ULK1CDK2CCNE1CCNK | |
| SCHEMBL25516689 | 0.82 | ULK1 (0.46) | MAPK3ULK1CDK2CCNE1CCNK | |
| SCHEMBL25522696 | 0.81 | ULK1 (0.55) | MAPK3ULK1CDK2CCNE1CCNK | |
| SCHEMBL25224397 | 0.81 | CDK2 (0.40) | MAPK3ULK1CDK2CCNE1CCNK | |
| SCHEMBL30397298 | 0.81 | CDK2 (0.40) | MAPK3ULK1CDK2CCNE1CCNK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023091726-A1 | INHIBITORS OF CYCLIN‑DEPENDENT KINASE 12 (CDK12) | SYROS PHARMACEUTICALS, INC. (US) | 2023-05-25 | — | — | WO | disclosed |