Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 11/20 | 0.39 |
| ▸ | CCNK | O75909 | 2/20 | 0.39 |
| ▸ | CDK12 | Q9NYV4 | 2/20 | 0.39 |
| ▸ | CDK7 | P50613 | 1/20 | 0.39 |
| ▸ | CCNH | P51946 | 1/20 | 0.39 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.38 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | IL1B | P01584 | 1/20 | 0.37 |
| ▸ | BTK | Q06187 | 1/20 | 0.37 |
| ▸ | HCRTR2 | O43614 | 5/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL25223128 | 1.00 | HCRTR1 (0.39) | HCRTR1CCNKCDK12CDK7CCNH | |
| SCHEMBL25539391 | 0.91 | CCNK (0.43) | HCRTR1CCNKCDK12CDK7CCNH | |
| SCHEMBL29749413 | 0.91 | CCNK (0.43) | HCRTR1CCNKCDK12CDK7CCNH | |
| Trifluoroacetic Acid SCHEMBL30915024 | 0.79 | HRH4 (0.49) | HCRTR1CCNKCDK12CHEK1PTGDR2 | |
| SCHEMBL30397933 | 0.72 | PTGDR2 (0.42) | HCRTR1CCNKCDK12PTGDR2HCRTR2 | |
| SCHEMBL28549701 | 0.71 | IDH2 (0.54) | CCNKCDK12CDK7CCNHMNAT1 | |
| SCHEMBL22895847 | 0.71 | IDH2 (0.54) | CCNKCDK12CDK7CCNHMNAT1 | |
| SCHEMBL31581713 | 0.71 | HCRTR1 (0.45) | HCRTR1CCNKCDK12PTGDR2HCRTR2 | |
| SCHEMBL26126794 | 0.70 | IDH2 (0.40) | HCRTR1 | |
| Hydrochloric Acid SCHEMBL29777672 | 0.70 | IDH2 (0.53) | CCNKCDK12CDK7CCNHMNAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023091726-A1 | INHIBITORS OF CYCLIN‑DEPENDENT KINASE 12 (CDK12) | SYROS PHARMACEUTICALS, INC. (US) | 2023-05-25 | — | — | WO | disclosed |