Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | IDH1 | O75874 | 15/20 | 0.44 |
| ▸ | IDH2 | P48735 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25226820 | 1.00 | GAA (0.47) | GAAKDM4EALDH1A1LMNAL3MBTL1 | |
| SCHEMBL25597187 | 0.85 | IDH1 (0.45) | GAAIDH1IDH2KCNH2LRRK2 | |
| SCHEMBL26977882 | 0.77 | ADORA2A (0.47) | GAAKDM4EALDH1A1L3MBTL1MAPT | |
| SCHEMBL9393281 | 0.75 | KMT2A (0.46) | GAAKDM4EALDH1A1LMNAL3MBTL1 | |
| SCHEMBL21550205 | 0.75 | GAA (0.44) | GAAKDM4EALDH1A1L3MBTL1IDH1 | |
| SCHEMBL3817806 | 0.75 | KDM4E (0.42) | GAAKDM4EALDH1A1L3MBTL1IDH1 | |
| SCHEMBL25678881 | 0.75 | CTSK (0.50) | GAAKDM4EALDH1A1IDH1LRRK2 | |
| SCHEMBL5764208 | 0.75 | KDM4E (0.48) | GAAKDM4EALDH1A1LMNAL3MBTL1 | |
| SCHEMBL20836481 | 0.74 | ULK1 (0.47) | GAAKDM4EALDH1A1LMNAL3MBTL1 | |
| SCHEMBL2527306 | 0.74 | PIN1 (0.59) | GAAKDM4EALDH1A1L3MBTL1IDH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023091726-A1 | INHIBITORS OF CYCLIN‑DEPENDENT KINASE 12 (CDK12) | SYROS PHARMACEUTICALS, INC. (US) | 2023-05-25 | — | — | WO | disclosed |