Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | CTSD | P07339 | 3/20 | 0.39 |
| ▸ | BACE1 | P56817 | 3/20 | 0.39 |
| ▸ | BACE2 | Q9Y5Z0 | 2/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.36 |
| ▸ | NAMPT | P43490 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2212006 | 0.97 | KMT2A (0.38) | KMT2AHPGDLMNACTSDBACE1 | |
| SCHEMBL3378334 | 0.88 | KMT2A (0.45) | KMT2AHPGDLMNAPKMALDH1A1 | |
| SCHEMBL302272 | 0.80 | KMT2A (0.51) | KMT2AHPGDLMNAALDH1A1NAMPT | |
| SCHEMBL303593 | 0.79 | LMNA (0.38) | KMT2AHPGDLMNAALDH1A1TSHR | |
| SCHEMBL3379839 | 0.78 | LMNA (0.56) | KMT2ALMNAALDH1A1MAPT | |
| SCHEMBL2211106 | 0.77 | LMNA (0.48) | KMT2AHPGDLMNAPKMALDH1A1 | |
| SCHEMBL3376397 | 0.75 | KMT2A (0.50) | KMT2AHPGDLMNAALDH1A1TSHR | |
| SCHEMBL303353 | 0.74 | LMNA (0.43) | KMT2ALMNACTSDBACE1BACE2 | |
| SCHEMBL17075498 | 0.74 | LMNA (0.45) | KMT2AHPGDLMNACTSDBACE1 | |
| SCHEMBL18487096 | 0.73 | MEN1 (0.46) | KMT2AALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2012500836-A | — | — | 2012-01-12 | — | — | JP | claimed |
| EP-2342177-A1 | NOVEL POTASSIUM CHANNEL BLOCKERS | Xention Limited (GB) | 2011-07-13 | — | — | EP | claimed |
| WO-2010023448-A1 | NOVEL POTASSIUM CHANNEL BLOCKERS | XENTION LIMITED (GB) | 2010-03-04 | — | — | WO | claimed |