Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 7/20 | 0.38 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.38 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 5/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3376397 | 0.86 | KMT2A (0.50) | LMNAAPOBEC3AAPOBEC3GTDP1TP53 | |
| SCHEMBL303989 | 0.79 | KMT2A (0.41) | LMNATSHRALDH1A1MAPTKMT2A | |
| SCHEMBL2212006 | 0.79 | KMT2A (0.38) | LMNATSHRALDH1A1MAPTKMT2A | |
| SCHEMBL3275527 | 0.78 | LMNA (0.51) | LMNATP53TSHRALDH1A1MAPT | |
| SCHEMBL304444 | 0.76 | MAPT (0.43) | LMNAALDH1A1MAPTKMT2AMEN1 | |
| SCHEMBL2189008 | 0.76 | LMNA (0.49) | LMNATSHRALDH1A1MAPTKMT2A | |
| SCHEMBL3376926 | 0.76 | MAPT (0.60) | LMNAALDH1A1MAPTKMT2AMEN1 | |
| SCHEMBL18487096 | 0.73 | MEN1 (0.46) | ALDH1A1MAPTKMT2AMEN1 | |
| SCHEMBL303353 | 0.73 | LMNA (0.43) | LMNATP53TSHRMAPTKMT2A | |
| SCHEMBL304469 | 0.72 | LMNA (0.48) | LMNAALDH1A1MAPTKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2012500836-A | — | — | 2012-01-12 | — | — | JP | claimed |
| EP-2342177-A1 | NOVEL POTASSIUM CHANNEL BLOCKERS | Xention Limited (GB) | 2011-07-13 | — | — | EP | claimed |
| WO-2010023448-A1 | NOVEL POTASSIUM CHANNEL BLOCKERS | XENTION LIMITED (GB) | 2010-03-04 | — | — | WO | claimed |