Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.40 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.40 |
| ▸ | HTR6 | P50406 | 3/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HTR7 | P34969 | 1/20 | 0.38 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26176365 | 1.00 | L3MBTL1 (0.48) | L3MBTL1ALDH1A1LMNASMN1; SMN2PKM | |
| SCHEMBL25209802 | 0.88 | L3MBTL1 (0.45) | L3MBTL1ALDH1A1LMNASMN1; SMN2PKM | |
| SCHEMBL30349392 | 0.88 | L3MBTL1 (0.45) | L3MBTL1ALDH1A1LMNASMN1; SMN2PKM | |
| SCHEMBL30542285 | 0.86 | L3MBTL1 (0.45) | L3MBTL1ALDH1A1LMNASMN1; SMN2PKM | |
| SCHEMBL20292779 | 0.85 | L3MBTL1 (0.53) | L3MBTL1ALDH1A1LMNASMN1; SMN2PKM | |
| SCHEMBL26176364 | 0.84 | L3MBTL1 (0.44) | L3MBTL1ALDH1A1LMNASMN1; SMN2PTPN11 | |
| SCHEMBL30400147 | 0.84 | L3MBTL1 (0.44) | L3MBTL1ALDH1A1LMNASMN1; SMN2PTPN11 | |
| SCHEMBL15805469 | 0.83 | L3MBTL1 (0.42) | L3MBTL1ALDH1A1LMNASMN1; SMN2PKM | |
| SCHEMBL20293040 | 0.82 | PTPN11 (0.48) | L3MBTL1ALDH1A1PKMPTPN11HTR6 | |
| SCHEMBL20744459 | 0.81 | L3MBTL1 (0.45) | L3MBTL1LMNASMN1; SMN2PKMHSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4415817-A1 | 1H-PYRROLO[2,3-B]PYRIDINES AS DYRK1A INHIBITORS | BioSplice Therapeutics, Inc. (US) | 2024-08-21 | — | — | EP | disclosed |
| WO-2023064349-A1 | 1H-PYRROLO[2,3-B]PYRIDINES AS DYRK1A INHIBITORS | BIOSPLICE THERAPEUTICS, INC. (US) | 2023-04-20 | — | — | WO | disclosed |