Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | HTR1D | P28221 | 1/20 | 0.42 |
| ▸ | HTR1B | P28222 | 1/20 | 0.42 |
| ▸ | HTR1F | P30939 | 1/20 | 0.42 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | TTK | P33981 | 1/20 | 0.39 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.39 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 15/20 | 0.37 |
| ▸ | WNT1 | P04628 | 4/20 | 0.37 |
| ▸ | GSK3B | P49841 | 4/20 | 0.37 |
| ▸ | CLK1 | P49759 | 2/20 | 0.36 |
| ▸ | MAPKAPK2 | P49137 | 2/20 | 0.36 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.36 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.36 |
| ▸ | CDC7 | O00311 | 1/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.36 |
| ▸ | CDK8 | P49336 | 1/20 | 0.36 |
| ▸ | MELK | Q14680 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26176177 | 1.00 | HTR1A (0.42) | HTR1AHTR1DHTR1BHTR1FAURKA | |
| SCHEMBL25263374 | 0.89 | MAPKAPK2 (0.42) | HTR1AHTR1DHTR1BHTR1FAURKA | |
| SCHEMBL30398369 | 0.89 | MAPKAPK2 (0.42) | HTR1AHTR1DHTR1BHTR1FAURKA | |
| SCHEMBL26176386 | 0.89 | JAK1 (0.39) | HTR1AHTR1DHTR1BHTR1FDYRK1A | |
| SCHEMBL30400429 | 0.89 | JAK1 (0.39) | HTR1AHTR1DHTR1BHTR1FDYRK1A | |
| SCHEMBL26176118 | 0.85 | DYRK1A (0.42) | HTR1AHTR1DHTR1BHTR1FDYRK1A | |
| SCHEMBL30399299 | 0.85 | DYRK1A (0.42) | HTR1AHTR1DHTR1BHTR1FDYRK1A | |
| SCHEMBL26175764 | 0.81 | ADORA2A (0.43) | DYRK1AGSK3BCLK1CLK4DYRK1B | |
| SCHEMBL26175725 | 0.80 | MAP3K11 (0.36) | AURKAAURKBDYRK1ADYRK1BCDC7 | |
| SCHEMBL30398345 | 0.80 | JAK1 (0.42) | HTR1AHTR1DHTR1BHTR1FDYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4415817-A1 | 1H-PYRROLO[2,3-B]PYRIDINES AS DYRK1A INHIBITORS | BioSplice Therapeutics, Inc. (US) | 2024-08-21 | — | — | EP | claimed |
| WO-2023064349-A1 | 1H-PYRROLO[2,3-B]PYRIDINES AS DYRK1A INHIBITORS | BIOSPLICE THERAPEUTICS, INC. (US) | 2023-04-20 | — | — | WO | claimed |
| EP-4415817-A1 | 1H-PYRROLO[2,3-B]PYRIDINES AS DYRK1A INHIBITORS | BioSplice Therapeutics, Inc. (US) | 2024-08-21 | — | — | EP | disclosed |
| WO-2023064349-A1 | 1H-PYRROLO[2,3-B]PYRIDINES AS DYRK1A INHIBITORS | BIOSPLICE THERAPEUTICS, INC. (US) | 2023-04-20 | — | — | WO | disclosed |