Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 9/20 | 0.42 |
| ▸ | JAK1 | P23458 | 3/20 | 0.42 |
| ▸ | GSK3B | P49841 | 9/20 | 0.42 |
| ▸ | WNT1 | P04628 | 3/20 | 0.41 |
| ▸ | HTR1A | P08908 | 4/20 | 0.41 |
| ▸ | HTR1F | P30939 | 4/20 | 0.41 |
| ▸ | ABL1 | P00519 | 3/20 | 0.41 |
| ▸ | HTR1D | P28221 | 3/20 | 0.41 |
| ▸ | HTR1B | P28222 | 3/20 | 0.41 |
| ▸ | GSK3A | P49840 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26176118 | 1.00 | DYRK1A (0.42) | DYRK1AJAK1GSK3BWNT1HTR1A | |
| SCHEMBL26176117 | 0.94 | JAK1 (0.42) | DYRK1AJAK1GSK3BWNT1HTR1A | |
| SCHEMBL30398345 | 0.94 | JAK1 (0.42) | DYRK1AJAK1GSK3BWNT1HTR1A | |
| SCHEMBL30400221 | 0.87 | ABL1 (0.42) | DYRK1AGSK3BWNT1ABL1 | |
| SCHEMBL26177062 | 0.87 | ABL1 (0.42) | DYRK1AGSK3BWNT1ABL1 | |
| SCHEMBL30399856 | 0.85 | HTR1A (0.42) | DYRK1AGSK3BWNT1HTR1AHTR1F | |
| SCHEMBL26176177 | 0.85 | HTR1A (0.42) | DYRK1AGSK3BWNT1HTR1AHTR1F | |
| SCHEMBL26175803 | 0.83 | CAMKK2 (0.37) | DYRK1AABL1 | |
| SCHEMBL30399194 | 0.83 | DYRK1A (0.43) | DYRK1AJAK1GSK3BWNT1HTR1A | |
| SCHEMBL26178421 | 0.83 | DYRK1A (0.43) | DYRK1AJAK1GSK3BWNT1HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4415817-A1 | 1H-PYRROLO[2,3-B]PYRIDINES AS DYRK1A INHIBITORS | BioSplice Therapeutics, Inc. (US) | 2024-08-21 | — | — | EP | claimed |
| WO-2023064349-A1 | 1H-PYRROLO[2,3-B]PYRIDINES AS DYRK1A INHIBITORS | BIOSPLICE THERAPEUTICS, INC. (US) | 2023-04-20 | — | — | WO | claimed |