Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 1/20 | 0.39 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.39 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.39 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.39 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.38 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | XDH | P47989 | 1/20 | 0.35 |
| ▸ | CCR6 | P51684 | 1/20 | 0.35 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 2/20 | 0.34 |
| ▸ | PPARA | Q07869 | 2/20 | 0.34 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.34 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25191584 | 1.00 | GABRA1 (0.39) | GABRA1GABRA5GABRA3GABRA2GABRA6 | |
| SCHEMBL25194933 | 0.73 | ALDH1A1 (0.34) | GRM1SMN1; SMN2KDM4EALDH1A1MEN1 | |
| SCHEMBL3597060 | 0.72 | MAPK1 (0.41) | GABRA1GABRA5GABRA3GABRA2GABRA6 | |
| SCHEMBL22890025 | 0.71 | NPSR1 (0.47) | GABRA1GABRA5GABRA3GABRA2GABRA6 | |
| SCHEMBL13755836 | 0.71 | NPSR1 (0.38) | GABRA1GABRA5GABRA3GABRA2GABRA6 | |
| SCHEMBL31431795 | 0.70 | POLB (0.40) | GABRA2NPSR1SMN1; SMN2HPGDKDM4E | |
| SCHEMBL19243186 | 0.70 | CYP1A2 (0.35) | NPSR1SMN1; SMN2KDM4EALDH1A1PPARG | |
| SCHEMBL31432429 | 0.69 | NPSR1 (0.48) | NPSR1SMN1; SMN2HPGDKDM4EALDH1A1 | |
| SCHEMBL27388974 | 0.69 | NPSR1 (0.44) | NPSR1SMN1; SMN2HPGDKDM4EALDH1A1 | |
| SCHEMBL25199463 | 0.68 | ALDH1A1 (0.32) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4430022-A1 | HETEROCYCLIC COMPOUNDS AS TRIGGERING RECEPTOR EXPRESSED ON MYELOID CELLS 2 AGONISTS AND METHODS OF USE | Vigil Neuroscience, Inc. (US) | 2024-09-18 | — | — | EP | disclosed |
| WO-2023086801-A1 | HETEROCYCLIC COMPOUNDS AS TRIGGERING RECEPTOR EXPRESSED ON MYELOID CELLS 2 AGONISTS AND METHODS OF USE | VIGIL NEUROSCIENCE, INC. (US) | 2023-05-19 | — | — | WO | disclosed |