Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | FYN | P06241 | 7/20 | 0.34 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 3/20 | 0.32 |
| ▸ | RAB9A | P51151 | 3/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.32 |
| ▸ | RELA | Q04206 | 1/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.32 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.32 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.32 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.32 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.32 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.32 |
| ▸ | MET | P08581 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1202203 | 0.69 | FYN (0.59) | FYNNPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL10246682 | 0.64 | TNF (0.57) | SMN1; SMN2KDM4EALDH1A1MKNK1 | |
| SCHEMBL481780 | 0.64 | KMT2A (0.41) | KMT2AKDM4EALDH1A1HPGDPIK3CA | |
| SCHEMBL22834762 | 0.64 | DYRK1A (0.57) | FYNNPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL23212218 | 0.63 | KMT2A (0.47) | KMT2AKDM4EMEN1 | |
| Ammonia Solution, Strong SCHEMBL6267830 | 0.62 | SLC6A2 (0.61) | RAB9AKDM4EALDH1A1NFKB1 | |
| SCHEMBL23278515 | 0.62 | TGFBR1 (0.36) | FYNDGAT1METMKNK1 | |
| Ammonia Solution, Strong SCHEMBL6989331 | 0.61 | TAAR1 (0.48) | KMT2AKDM4EALDH1A1 | |
| Ammonia Solution, Strong SCHEMBL7891727 | 0.61 | TAAR1 (0.48) | KMT2AKDM4EALDH1A1 | |
| SCHEMBL22780620 | 0.61 | ASIC3 (0.46) | KMT2AALDH1A1PIK3CAAKT1MTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100216798-A1 | FUSED HETEROCYCLES AS LCK INHIBITORS | ASTELLAS PHARMA INC (JP) | 2010-08-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100216798-A1 | FUSED HETEROCYCLES AS LCK INHIBITORS | LCK, ZAP70, FYN | KMT2A 547/4885FYN 3/4885DGAT1 4588/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.