Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | HRH2 | P25021 | 16/20 | 0.54 |
| ▸ | HRH1 | P35367 | 16/20 | 0.54 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | HTR7 | P34969 | 1/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9405372 | 0.85 | POLB (0.73) | SMN1; SMN2LMNAPOLBHRH2HRH1 | |
| SCHEMBL46979 | 0.84 | SMN1; SMN2 (0.56) | SMN1; SMN2LMNAPOLBHRH2HRH1 | |
| SCHEMBL3966262 | 0.84 | SMN1; SMN2 (0.56) | SMN1; SMN2LMNAPOLBHRH2HRH1 | |
| SCHEMBL29991910 | 0.83 | HRH2 (0.56) | SMN1; SMN2LMNAPOLBHRH2HRH1 | |
| SCHEMBL27166403 | 0.83 | HRH2 (0.56) | SMN1; SMN2LMNAPOLBHRH2HRH1 | |
| SCHEMBL4199473 | 0.82 | SMN1; SMN2 (0.54) | SMN1; SMN2LMNAPOLBHRH2HRH1 | |
| SCHEMBL5594524 | 0.82 | POLB (0.65) | SMN1; SMN2LMNAPOLBHRH2HRH1 | |
| SCHEMBL28015674 | 0.81 | HRH2 (0.54) | SMN1; SMN2LMNAPOLBHRH2HRH1 | |
| SCHEMBL29991263 | 0.80 | SMN1; SMN2 (0.51) | SMN1; SMN2LMNAPOLBHRH2HRH1 | |
| SCHEMBL14670199 | 0.78 | HRH2 (0.56) | SMN1; SMN2POLBHRH2HRH1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4168002-A1 | METHODS FOR DELAYING, PREVENTING, AND TREATING ACQUIRED RESISTANCE TO RAS INHIBITORS | Revolution Medicines, Inc. (US) | 2023-04-26 | — | — | EP | disclosed |