Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | HRH2 | P25021 | 16/20 | 0.52 |
| ▸ | HRH1 | P35367 | 16/20 | 0.52 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | HTR7 | P34969 | 1/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28015674 | 0.84 | HRH2 (0.54) | SMN1; SMN2LMNAPOLBHRH2HRH1 | |
| SCHEMBL9405372 | 0.82 | POLB (0.73) | SMN1; SMN2LMNAPOLBHRH2HRH1 | |
| SCHEMBL30404652 | 0.82 | SMN1; SMN2 (0.56) | SMN1; SMN2LMNAPOLBHRH2HRH1 | |
| SCHEMBL3966262 | 0.82 | SMN1; SMN2 (0.56) | SMN1; SMN2LMNAPOLBHRH2HRH1 | |
| SCHEMBL46979 | 0.82 | SMN1; SMN2 (0.56) | SMN1; SMN2LMNAPOLBHRH2HRH1 | |
| SCHEMBL29991910 | 0.81 | HRH2 (0.56) | SMN1; SMN2LMNAPOLBHRH2HRH1 | |
| SCHEMBL27166403 | 0.81 | HRH2 (0.56) | SMN1; SMN2LMNAPOLBHRH2HRH1 | |
| SCHEMBL5544347 | 0.80 | HRH2 (0.53) | SMN1; SMN2LMNAPOLBHRH2HRH1 | |
| SCHEMBL5594524 | 0.79 | POLB (0.65) | SMN1; SMN2LMNAPOLBHRH2HRH1 | |
| SCHEMBL5546645 | 0.79 | HRH2 (0.52) | SMN1; SMN2LMNAPOLBHRH2HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2032559-A1 | 2-HETEROCYCLOAMINO-4-IMIDAZOLYLPYRIMIDINES AS AGENTS FOR THE INHIBITION OF CELL PROLIFERATION | AstraZeneca AB (SE) | 2009-03-11 | — | — | EP | disclosed |
| WO-2007138268-A1 | 2-HETEROCYCLOAMINO-4-IMIDAZOLYLPYRIMIDINES AS AGENTS FOR THE INHIBITION OF CELL PROLIFERATION | ASTRAZENECA AB (SE) | 2007-12-06 | — | — | WO | disclosed |