Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.45 |
| ▸ | RAB9A | P51151 | 4/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | CYP4F2 | P78329 | 3/20 | 0.43 |
| ▸ | CYP4A11 | Q02928 | 3/20 | 0.43 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.42 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.41 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.41 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18105802 | 0.83 | MAOB (0.51) | CYP4F2CYP4A11SLC7A5ALDH1A1NPSR1 | |
| SCHEMBL11427053 | 0.81 | ALDH1A1 (0.57) | SMN1; SMN2RAB9ANPC1KMT2AMEN1 | |
| SCHEMBL14101266 | 0.81 | HSD11B1 (0.52) | SMN1; SMN2RAB9ANPC1LMNABRD4 | |
| SCHEMBL791928 | 0.81 | SMN1; SMN2 (0.49) | SMN1; SMN2RAB9ANPC1LMNAKMT2A | |
| SCHEMBL18105797 | 0.81 | MAOB (0.49) | CYP4F2CYP4A11SLC7A5MRGPRX4 | |
| SCHEMBL18106017 | 0.81 | MAOB (0.49) | CYP4F2CYP4A11SLC7A5MRGPRX4 | |
| SCHEMBL18105989 | 0.81 | MAOB (0.49) | CYP4F2CYP4A11SLC7A5MRGPRX4 | |
| SCHEMBL18106016 | 0.81 | MAOB (0.49) | CYP4F2CYP4A11SLC7A5MRGPRX4 | |
| SCHEMBL18106019 | 0.81 | MAOB (0.49) | CYP4F2CYP4A11SLC7A5MRGPRX4 | |
| SCHEMBL5277923 | 0.81 | CYP4F2 (0.68) | SMN1; SMN2RAB9ANPC1CYP4F2CYP4A11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4419508-A2 | OXAZOLE, OXADIAZOLE, AND INDOLE DERIVATIVES FOR THE INHIBITION OF USP28 | Carmot Therapeutics, Inc. (US) | 2024-08-28 | — | — | EP | disclosed |
| CN-118302414-A | Oxazole, oxadiazole and indole derivatives useful for inhibiting USP28 | 卡莫特医疗有限公司 | 2024-07-05 | — | — | CN | disclosed |
| WO-2023069721-A2 | OXAZOLE, OXADIAZOLE, AND INDOLE DERIVATIVES FOR THE INHIBITION OF USP28 | CARMOT THERAPEUTICS, INC. (US) | 2023-04-27 | — | — | WO | disclosed |