Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNC | P24863 | 2/20 | 0.48 |
| ▸ | CDK8 | P49336 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | GALR3 | O60755 | 1/20 | 0.43 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.38 |
| ▸ | TYMS | P04818 | 1/20 | 0.38 |
| ▸ | PDE1A | P54750 | 1/20 | 0.38 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25515855 | 0.74 | KDM4E (0.52) | POLBKDM4EMAPTALDH1A1GAA | |
| SCHEMBL15215746 | 0.71 | ALDH1A1 (0.56) | POLBKDM4EMAPTALDH1A1GAA | |
| Hydrochloric Acid SCHEMBL7585345 | 0.70 | ALDH1A1 (0.59) | CCNCCDK8POLBKDM4EMAPT | |
| SCHEMBL12596382 | 0.70 | POLB (0.61) | CCNCCDK8POLBKDM4EMAPT | |
| SCHEMBL21332695 | 0.68 | KDM4E (0.42) | POLBKDM4EMAPTALDH1A1GAA | |
| SCHEMBL22516485 | 0.67 | GALR3 (0.51) | CCNCCDK8POLBKDM4EMAPT | |
| SCHEMBL25193801 | 0.67 | CCNC (0.48) | CCNCCDK8POLBKDM4EMAPT | |
| SCHEMBL15180941 | 0.67 | P2RX3 (0.47) | POLBKDM4EMAPTALDH1A1GAA | |
| SCHEMBL15015960 | 0.66 | P2RX3 (0.47) | POLBKDM4EMAPTALDH1A1GAA | |
| SCHEMBL28026195 | 0.66 | CYP2C19 (0.59) | POLBKDM4EALDH1A1GAANR2F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023078337-A1 | CDK8/19 DUAL INHIBITORS AND METHODS OF USE | INSILICO MEDICINE IP LIMITED (CN) | 2023-05-11 | — | — | WO | disclosed |