Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.61 |
| ▸ | MAPT | P10636 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | GALR3 | O60755 | 1/20 | 0.54 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | CCNC | P24863 | 4/20 | 0.51 |
| ▸ | CDK8 | P49336 | 4/20 | 0.51 |
| ▸ | CLK1 | P49759 | 1/20 | 0.51 |
| ▸ | CLK2 | P49760 | 1/20 | 0.51 |
| ▸ | GSK3A | P49840 | 1/20 | 0.51 |
| ▸ | GSK3B | P49841 | 1/20 | 0.51 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.51 |
| ▸ | LATS2 | Q9NRM7 | 1/20 | 0.51 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.51 |
| ▸ | CSNK1G3 | Q9Y6M4 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1770378 | 0.87 | POLB (0.53) | POLBKDM4EMAPTALDH1A1GALR3 | |
| SCHEMBL9504656 | 0.80 | KDM4E (0.60) | POLBKDM4EALDH1A1GSK3AGSK3B | |
| Hydrochloric Acid SCHEMBL7585345 | 0.75 | ALDH1A1 (0.59) | POLBKDM4EMAPTALDH1A1GALR3 | |
| SCHEMBL15215745 | 0.72 | ALDH1A1 (0.52) | POLBKDM4EMAPTALDH1A1GALR3 | |
| SCHEMBL12596283 | 0.72 | KCNH2 (0.61) | POLBKDM4EMAPTGALR3NR2F2 | |
| SCHEMBL11719377 | 0.72 | P2RX3 (0.54) | POLBKDM4EMAPTALDH1A1SMN1; SMN2 | |
| Chlormidazole SCHEMBL148113 | 0.71 | GALR3 (1.00) | ALDH1A1GALR3NR2F2RAB9AGSK3B | |
| Chlormidazole SCHEMBL30402878 | 0.71 | GALR3 (1.00) | ALDH1A1GALR3NR2F2RAB9AGSK3B | |
| SCHEMBL12045850 | 0.70 | P2RX3 (0.52) | KDM4EALDH1A1GALR3NR2F2RAB9A | |
| Chlormidazole SCHEMBL364033 | 0.70 | GALR3 (0.97) | MAPTALDH1A1GALR3NR2F2RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110112151-A1 | COMPOUND CAPABLE OF INHIBITING 11-BETA HYDROXYSTERIOD DEHYDROGENASE | STERIX LIMITED (GB) | 2011-05-12 | — | — | US | disclosed |
| US-20110112151-A1 | COMPOUND CAPABLE OF INHIBITING 11-BETA HYDROXYSTERIOD DEHYDROGENASE | STERIX LIMITED (GB) | 2011-05-12 | — | — | US | disclosed |
| WO-2009106817-A2 | COMPOUND | STERIX LIMITED (GB) | 2009-09-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110112151-A1 | COMPOUND CAPABLE OF INHIBITING 11-BETA HYDROXYSTERIOD DEHYDROGENASE | HSD11B1, HSD11B2, HSD3B1 | POLB 1401/4885KDM4E 1739/4885MAPT 4681/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.