Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 14/20 | 0.38 |
| ▸ | MAOB | P27338 | 2/20 | 0.34 |
| ▸ | THRA | P10827 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.33 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.33 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | DRD4 | P21917 | 1/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3039044 | 0.96 | HRH3 (0.37) | MAPTHRH3MAOBTHRATHRB | |
| SCHEMBL3207189 | 0.92 | HRH3 (0.38) | MAPTHRH3MAOBTHRATHRB | |
| SCHEMBL3213924 | 0.92 | HRH3 (0.38) | MAPTHRH3THRATHRBHPGD | |
| SCHEMBL3042124 | 0.91 | HRH3 (0.33) | MAPTHRH3HPGDCHRM2CHRM4 | |
| SCHEMBL3036691 | 0.91 | THRA (0.37) | HRH3THRATHRBDRD2DRD4 | |
| SCHEMBL3032436 | 0.88 | SLC6A2 (0.36) | MAPTHRH3THRATHRBDRD2 | |
| SCHEMBL3037414 | 0.88 | TP53 (0.37) | HRH3THRATHRB | |
| SCHEMBL3210078 | 0.87 | HRH3 (0.36) | MAPTHRH3MAOBHPGDDRD2 | |
| SCHEMBL13219242 | 0.85 | PDK2 (0.33) | HRH3THRATHRBDRD2DRD4 | |
| SCHEMBL13219248 | 0.83 | ACHE (0.36) | HRH3THRATHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9249136-B2 | 3H-naphtho [2,1-B] pyrans as photochromic dichroic dyes and optical article containing them | ESSILOR INTERNATIONAL (COMPAGNIE GENERALE D'OPTIQUE) (FR) | 2016-02-02 | — | — | US | disclosed |
| US-9249136-B2 | 3H-naphtho [2,1-B] pyrans as photochromic dichroic dyes and optical article containing them | ESSILOR INTERNATIONAL (COMPAGNIE GENERALE D'OPTIQUE) (FR) | 2016-02-02 | — | — | US | disclosed |
| EP-2066650-B1 | 3H-NAPHTHO[2,1-B]PYRANS AS PHOTOCHROMIC DICHROIC DYES AND OPTICAL ARTICLE CONTAINING THEM | ESSILOR INT (FR) | 2011-12-21 | — | — | EP | disclosed |
| US-20100202033-A1 | 3H-NAPHTH0 [2,1-B] PYRANS AS PHOTOCHROMIC DICHROIC DYES AND OPTICAL ARTICLE CONTAINING THEM | ESSILOR INTERNATIONAL (COMPAGNIE GENERALE D' OPTIQUE) (FR) | 2010-08-12 | — | — | US | disclosed |
| US-20100202033-A1 | 3H-NAPHTH0 [2,1-B] PYRANS AS PHOTOCHROMIC DICHROIC DYES AND OPTICAL ARTICLE CONTAINING THEM | ESSILOR INTERNATIONAL (COMPAGNIE GENERALE D' OPTIQUE) (FR) | 2010-08-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100202033-A1 | 3H-NAPHTH0 [2,1-B] PYRANS AS PHOTOCHROMIC DICHROIC DYES AND OPTICAL ARTICLE CONTAINING THEM | NR0B1, NR0B2, NR4A1 | MAPT 4224/4885HRH3 533/4885MAOB 1608/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.