Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 8/20 | 0.58 |
| ▸ | AKT1 | P31749 | 1/20 | 0.46 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.42 |
| ▸ | KIT | P10721 | 3/20 | 0.40 |
| ▸ | KDR | P35968 | 3/20 | 0.40 |
| ▸ | FLT3 | P36888 | 2/20 | 0.40 |
| ▸ | NOS3 | P29474 | 1/20 | 0.39 |
| ▸ | NOS2 | P35228 | 1/20 | 0.39 |
| ▸ | BACE1 | P56817 | 1/20 | 0.39 |
| ▸ | F2 | P00734 | 1/20 | 0.39 |
| ▸ | F10 | P00742 | 1/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2634187 | 1.00 | EPHX2 (0.58) | EPHX2AKT1TBK1KITKDR | |
| SCHEMBL18302280 | 0.86 | EPHX2 (0.56) | EPHX2AKT1TBK1KITKDR | |
| SCHEMBL12025165 | 0.82 | ALDH1A1 (0.43) | EPHX2AKT1 | |
| SCHEMBL13202676 | 0.79 | EPHX2 (0.58) | EPHX2BRD4 | |
| SCHEMBL13893639 | 0.77 | NPC1 (0.38) | EPHX2AKT1F2F10 | |
| SCHEMBL6088948 | 0.76 | PIKFYVE (0.37) | EPHX2AKT1F2F10 | |
| SCHEMBL2441701 | 0.76 | HTR3A (0.40) | — | |
| SCHEMBL8358457 | 0.75 | NPC1 (0.45) | KITKDRFLT3 | |
| SCHEMBL18015728 | 0.75 | EPHX2 (0.54) | EPHX2 | |
| SCHEMBL12031404 | 0.75 | AKT1 (0.41) | EPHX2AKT1F2F10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023081661-A1 | BICYCLIC DERIVATIVES AS CCR2 MODULATORS | ARIA PHARMACEUTICALS, INC. (US) | 2023-05-11 | — | — | WO | disclosed |