Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | CASP3 | P42574 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.36 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.36 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | AKT1 | P31749 | 1/20 | 0.36 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.35 |
| ▸ | DHFR | P00374 | 1/20 | 0.33 |
| ▸ | F9 | P00740 | 2/20 | 0.32 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.32 |
| ▸ | IDO1 | P14902 | 2/20 | 0.32 |
| ▸ | F2RL3 | Q96RI0 | 1/20 | 0.32 |
| ▸ | F10 | P00742 | 3/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12025165 | 0.83 | ALDH1A1 (0.43) | NPC1RAB9AMAPTLMNASMN1; SMN2 | |
| SCHEMBL6088948 | 0.83 | PIKFYVE (0.37) | MAPTEPHX2AKT1F9IDO1 | |
| SCHEMBL2634187 | 0.77 | EPHX2 (0.58) | EPHX2AKT1F10F2 | |
| SCHEMBL30410154 | 0.77 | EPHX2 (0.58) | EPHX2AKT1F10F2 | |
| SCHEMBL14039533 | 0.75 | F9 (0.36) | NPC1RAB9ALMNASMN1; SMN2EPHX2 | |
| SCHEMBL12044601 | 0.73 | RAB9A (0.41) | NPC1RAB9AMAPTLMNASMN1; SMN2 | |
| SCHEMBL16806204 | 0.71 | SMN1; SMN2 (0.41) | NPC1RAB9AMAPTLMNAMAPK1 | |
| SCHEMBL6090589 | 0.71 | F9 (0.36) | EPHX2F9IDO1ESR1ESR2 | |
| SCHEMBL18683348 | 0.71 | IDO1 (0.50) | AKT1F9IDO1F10F2 | |
| SCHEMBL1759452 | 0.71 | MAPT (0.50) | MAPTLMNASMN1; SMN2F9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7514566-B2 | Thiazole compounds and methods of use | AMGEN, INC. (US) | 2009-04-07 | — | — | US | disclosed |
| US-20070173506-A1 | Thiazole compounds and methods of use | AMGEN INC. (US) | 2007-07-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070173506-A1 | Thiazole compounds and methods of use | MTOR, JAK2, PCK2 | NPC1 882/4885RAB9A 3573/4885MAPT 2718/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.