Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGKA | P23743 | 10/20 | 0.79 |
| ▸ | DGKZ | Q13574 | 9/20 | 0.79 |
| ▸ | DGKI | O75912 | 3/20 | 0.79 |
| ▸ | DGKG | P49619 | 2/20 | 0.79 |
| ▸ | DGKB | Q9Y6T7 | 2/20 | 0.79 |
| ▸ | DGKK | Q5KSL6 | 1/20 | 0.79 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.41 |
| ▸ | HTR1A | P08908 | 2/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.41 |
| ▸ | DRD1 | P21728 | 2/20 | 0.41 |
| ▸ | TBXA2R | P21731 | 2/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.41 |
| ▸ | DRD3 | P35462 | 2/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.41 |
| ▸ | BCL2 | P10415 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23293351 | 1.00 | DGKA (0.79) | DGKADGKZDGKIDGKGDGKB | |
| SCHEMBL23293353 | 1.00 | DGKA (0.79) | DGKADGKZDGKIDGKGDGKB | |
| SCHEMBL30616465 | 0.95 | DGKA (0.83) | DGKADGKZDGKIDGKGDGKB | |
| SCHEMBL23293196 | 0.95 | DGKA (0.83) | DGKADGKZDGKIDGKGDGKB | |
| SCHEMBL29654799 | 0.88 | DGKA (1.00) | DGKADGKZDGKIDGKGDGKB | |
| SCHEMBL21830991 | 0.88 | DGKA (1.00) | DGKADGKZDGKIDGKGDGKB | |
| SCHEMBL23293267 | 0.88 | DGKA (0.72) | DGKADGKZDGKIDGKGDGKB | |
| SCHEMBL23293583 | 0.87 | DGKA (0.77) | DGKADGKZDGKIDGKGDGKB | |
| SCHEMBL23293580 | 0.87 | DGKA (0.77) | DGKADGKZDGKIDGKGDGKB | |
| SCHEMBL23293283 | 0.85 | DGKZ (0.68) | DGKADGKZDGKIDGKGDGKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3814347-B1 | NAPHTHYRIDINONE COMPOUNDS USEFUL AS T CELL ACTIVATORS | BRISTOL MYERS SQUIBB CO (US) | 2023-05-03 | — | — | EP | disclosed |