Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NUDT1 | P36639 | 3/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.39 |
| ▸ | BACE1 | P56817 | 2/20 | 0.39 |
| ▸ | BACE2 | Q9Y5Z0 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.36 |
| ▸ | CTSK | P43235 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.33 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.33 |
| ▸ | PDE1A | P54750 | 1/20 | 0.33 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.33 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.33 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.33 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.33 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29047990 | 1.00 | NUDT1 (0.42) | NUDT1PIK3CABACE1BACE2SMN1; SMN2 | |
| SCHEMBL24253757 | 1.00 | NUDT1 (0.42) | NUDT1PIK3CABACE1BACE2SMN1; SMN2 | |
| SCHEMBL30424176 | 0.82 | OPRK1 (0.46) | NUDT1PIK3CASMN1; SMN2HRH4OPRK1 | |
| SCHEMBL29047997 | 0.82 | OPRK1 (0.46) | NUDT1PIK3CASMN1; SMN2HRH4OPRK1 | |
| SCHEMBL24253756 | 0.82 | OPRK1 (0.46) | NUDT1PIK3CASMN1; SMN2HRH4OPRK1 | |
| SCHEMBL3727913 | 0.82 | NUDT1 (0.46) | NUDT1PIK3CABACE1BACE2HRH4 | |
| SCHEMBL3199851 | 0.73 | OPRK1 (0.51) | NUDT1PIK3CASMN1; SMN2HRH4OPRK1 | |
| SCHEMBL6235685 | 0.73 | CTSK (0.43) | HRH4CTSKMKNK1MKNK2 | |
| SCHEMBL15756954 | 0.72 | NUDT1 (0.77) | NUDT1PIK3CAPDE1APDE1B | |
| SCHEMBL18284684 | 0.70 | MKNK1 (0.39) | BACE1BACE2CTSKMKNK1MKNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4196478-A1 | HETEROARYL SUBSTITUTED SPIROPIPERIDINYL DERIVATIVES AND PHARMACEUTICAL USES THEREOF | Novartis AG (CH) | 2023-06-21 | — | — | EP | disclosed |
| CN-116157404-A | Heteroaryl substituted spiropiperidinyl derivatives and pharmaceutical uses thereof | 诺华股份有限公司 | 2023-05-23 | — | — | CN | disclosed |