Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EP300 | Q09472 | 3/20 | 0.32 |
| ▸ | TNKS | O95271 | 1/20 | 0.30 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
| ▸ | MAOB | P27338 | 2/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | MAOA | P21397 | 1/20 | 0.30 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.30 |
| ▸ | CALML3 | P27482 | 1/20 | 0.30 |
| ▸ | SDHA | P31040 | 1/20 | 0.30 |
| ▸ | BRD4 | O60885 | 2/20 | 0.30 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.30 |
| ▸ | BRD2 | P25440 | 1/20 | 0.30 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24253508 | 1.00 | EP300 (0.32) | EP300TNKSTNKS2ALDH1A1GAA | |
| SCHEMBL24253855 | 0.85 | EP300 (0.34) | EP300BRD4CREBBPBRD2BRD3 | |
| SCHEMBL30423647 | 0.85 | EP300 (0.34) | EP300BRD4CREBBPBRD2BRD3 | |
| SCHEMBL24253950 | 0.82 | GPR119 (0.36) | EP300 | |
| SCHEMBL24253847 | 0.81 | ADRA1D (0.33) | HTR1ADRD2ADRA1DADRA1AADRA1B | |
| SCHEMBL30423914 | 0.81 | PDE10A (0.37) | EP300MAPTBRD4CREBBPBRD2 | |
| SCHEMBL24253951 | 0.81 | PDE10A (0.37) | EP300MAPTBRD4CREBBPBRD2 | |
| SCHEMBL24253519 | 0.81 | HCRTR1 (0.33) | ALDH1A1GAAMAPTALOX15ALOX12 | |
| SCHEMBL24253607 | 0.80 | HTR1A (0.35) | MAPTHTR1ADRD2ADRA1DADRA1A | |
| SCHEMBL24253653 | 0.79 | PDE10A (0.41) | EP300 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4196478-A1 | HETEROARYL SUBSTITUTED SPIROPIPERIDINYL DERIVATIVES AND PHARMACEUTICAL USES THEREOF | Novartis AG (CH) | 2023-06-21 | — | — | EP | disclosed |
| CN-116157404-A | Heteroaryl substituted spiropiperidinyl derivatives and pharmaceutical uses thereof | 诺华股份有限公司 | 2023-05-23 | — | — | CN | disclosed |