SCHEMBL30424403

SCHEMBL30424403

[2H]c1cc(OC(F)(F)F)ccc1N1CCNCC1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADRB1 P08588 7/20 0.49
HTR3E A5X5Y0 5/20 0.49
HTR3B O95264 5/20 0.49
HTR3A P46098 5/20 0.49
HTR3D Q70Z44 5/20 0.49
HTR3C Q8WXA8 5/20 0.49
SIGMAR1 Q99720 5/20 0.49
LTA4H P09960 4/20 0.46
SCN4A P35499 1/20 0.46
SCN9A Q15858 1/20 0.46
PIM1 P11309 1/20 0.42
HTR1D P28221 2/20 0.41
HTR1A P08908 1/20 0.41
HTR1B P28222 1/20 0.41
ALDH1A1 P00352 1/20 0.41
HTR2C P28335 1/20 0.41
HTR5A P47898 1/20 0.41
MAPT P10636 1/20 0.40
THRB P10828 1/20 0.40
KCNA5 P22460 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL59331 0.89 ADRB1 (0.61) ADRB1HTR3EHTR3BHTR3AHTR3D
Hydrochloric Acid SCHEMBL28885740 0.87 ADRB1 (0.59) ADRB1HTR3EHTR3BHTR3AHTR3D
SCHEMBL14341118 0.84 ADRB1 (0.56) ADRB1HTR3EHTR3BHTR3AHTR3D
SCHEMBL5233334 0.83 ADRB1 (0.54) ADRB1HTR3EHTR3BHTR3AHTR3D
SCHEMBL31641797 0.81 HTR3E (0.54) ADRB1HTR3EHTR3BHTR3AHTR3D
SCHEMBL30567165 0.80 ADRB1 (0.57) ADRB1HTR3EHTR3BHTR3AHTR3D
SCHEMBL31466001 0.76 SCN4A (0.44) ADRB1HTR3EHTR3BHTR3AHTR3D
SCHEMBL5543670 0.75 L3MBTL3 (0.49) ADRB1HTR3EHTR3BHTR3AHTR3D
SCHEMBL1735099 0.75 ADRB1 (0.64) ADRB1HTR3EHTR3BHTR3AHTR3D
SCHEMBL3937241 0.75 ADRB1 (0.56) ADRB1HTR3EHTR3BHTR3AHTR3D

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116171272-A Novel VDAC1 inhibitors 阿巴尔塞奥制药公司 2023-05-26 CN disclosed