Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGK1 | P00558 | 1/20 | 0.42 |
| ▸ | RET | P07949 | 8/20 | 0.42 |
| ▸ | PPARG | P37231 | 2/20 | 0.40 |
| ▸ | PPARA | Q07869 | 2/20 | 0.40 |
| ▸ | PPARD | Q03181 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 4/20 | 0.40 |
| ▸ | DRD4 | P21917 | 3/20 | 0.40 |
| ▸ | WNT1 | P04628 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.38 |
| ▸ | ADK | P55263 | 1/20 | 0.38 |
| ▸ | WNT3A | P56704 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25268453 | 1.00 | PGK1 (0.42) | PGK1RETPPARGPPARAPPARD | |
| SCHEMBL25222092 | 0.87 | SMN1; SMN2 (0.46) | DRD2DRD4WNT1GSK3BDYRK1A | |
| SCHEMBL25348314 | 0.85 | RET (0.42) | PGK1RETPPARGPPARAPPARD | |
| SCHEMBL30520181 | 0.85 | RET (0.42) | PGK1RETPPARGPPARAPPARD | |
| SCHEMBL25217610 | 0.83 | SMARCA2 (0.44) | PGK1RETWNT1GSK3BDYRK1A | |
| SCHEMBL30429277 | 0.83 | SMARCA2 (0.44) | PGK1RETWNT1GSK3BDYRK1A | |
| SCHEMBL7346164 | 0.79 | UBE2T (0.44) | PGK1RETPPARGPPARAWNT1 | |
| SCHEMBL25218787 | 0.78 | CNR1 (0.45) | WNT1GSK3BDYRK1A | |
| SCHEMBL31140048 | 0.77 | PPARG (0.53) | RETPPARGPPARAPPARDDRD2 | |
| SCHEMBL24880642 | 0.77 | PPARG (0.53) | RETPPARGPPARAPPARDDRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4192835-A1 | 6-SUBSTITUTED PYRIDAZINE COMPOUNDS AS SMARCA2 AND/OR SMARCA4 DEGRADERS | Aurigene Oncology Limited (IN) | 2023-06-14 | — | — | EP | disclosed |