Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | UBE2T | Q9NPD8 | 1/20 | 0.44 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | PPARA | Q07869 | 1/20 | 0.38 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | ITGB3 | P05106 | 3/20 | 0.38 |
| ▸ | ITGA2B | P08514 | 3/20 | 0.38 |
| ▸ | WNT3A | P56704 | 1/20 | 0.38 |
| ▸ | PGK1 | P00558 | 1/20 | 0.38 |
| ▸ | RET | P07949 | 6/20 | 0.38 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.38 |
| ▸ | WNT1 | P04628 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.37 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.37 |
| ▸ | ADK | P55263 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7353169 | 0.85 | ITGB3 (0.53) | ITGB3ITGA2BGPR119 | |
| SCHEMBL7346169 | 0.84 | UBE2T (0.43) | UBE2TOPRM1OPRK1ITGB3ITGA2B | |
| SCHEMBL7381654 | 0.84 | UBE2T (0.51) | UBE2TOPRM1OPRK1ITGB3ITGA2B | |
| SCHEMBL7346577 | 0.82 | ITGB3 (0.52) | UBE2TITGB3ITGA2BCRBNWNT1 | |
| SCHEMBL25268453 | 0.79 | PGK1 (0.42) | PPARGPPARAWNT3APGK1RET | |
| SCHEMBL30429285 | 0.79 | PGK1 (0.42) | PPARGPPARAWNT3APGK1RET | |
| Trifluoroacetic Acid SCHEMBL7344932 | 0.78 | ITGB3 (0.49) | UBE2TPPARGPPARAITGB3ITGA2B | |
| SCHEMBL24880642 | 0.78 | PPARG (0.53) | PPARGPPARARETGPR119 | |
| SCHEMBL31140048 | 0.78 | PPARG (0.53) | PPARGPPARARETGPR119 | |
| SCHEMBL30520181 | 0.77 | RET (0.42) | PPARGPPARAPGK1RETWNT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0637304-A1 | 1-PIPERAZINEACETIC DERIVATIVES AS FIBRINOGEN RECEPTOR ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 1995-02-08 | — | — | EP | disclosed |
| WO-1993022303-A1 | 1-PIPERAZINEACETIC DERIVATIVES AS FIBRINOGEN RECEPTOR ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 1993-11-11 | — | — | WO | disclosed |