Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMO | O15229 | 10/20 | 0.61 |
| ▸ | KCNQ3 | O43525 | 2/20 | 0.46 |
| ▸ | KCNQ2 | O43526 | 2/20 | 0.46 |
| ▸ | KCNQ5 | Q9NR82 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | GRM5 | P41594 | 3/20 | 0.44 |
| ▸ | MET | P08581 | 1/20 | 0.43 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.42 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.42 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.42 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.41 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1938448 | 1.00 | KMO (0.61) | KMOKCNQ3KCNQ2KCNQ5NPC1 | |
| SCHEMBL1939335 | 0.90 | KMO (0.65) | KMOKCNQ3KCNQ2GRM5KCNE1 | |
| SCHEMBL30429046 | 0.90 | KMO (0.65) | KMOKCNQ3KCNQ2GRM5KCNE1 | |
| SCHEMBL1939132 | 0.88 | CYP11B2 (0.59) | KMOMETCYP11B1CYP11B2 | |
| SCHEMBL30429279 | 0.88 | CYP11B2 (0.59) | KMOMETCYP11B1CYP11B2 | |
| SCHEMBL14742201 | 0.86 | KMO (0.61) | KMOGRM5KDR | |
| SCHEMBL14742507 | 0.84 | KMO (0.62) | KMOKCNQ3KCNQ2KCNQ5GRM5 | |
| SCHEMBL30459590 | 0.84 | KMO (0.62) | KMOKCNQ3KCNQ2KCNQ5GRM5 | |
| SCHEMBL30429642 | 0.84 | KMO (0.75) | KMOGRM5 | |
| SCHEMBL1938796 | 0.84 | KMO (0.75) | KMOGRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116323583-A | Heterobiaryl compounds and imaging agents for imaging huntingtin | CHDI基金会股份有限公司 | 2023-06-23 | — | — | CN | disclosed |
| EP-4192819-A1 | HETEROBIARYL COMPOUNDS AND IMAGING AGENTS FOR IMAGING HUNTINGTIN PROTEIN | CHDI Foundation, Inc. (US) | 2023-06-14 | — | — | EP | disclosed |