Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DCLK1 | O15075 | 1/20 | 0.61 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.61 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.61 |
| ▸ | EGFR | P00533 | 1/20 | 0.61 |
| ▸ | PRKACA | P17612 | 1/20 | 0.61 |
| ▸ | FLT3 | P36888 | 1/20 | 0.61 |
| ▸ | FRK | P42685 | 1/20 | 0.61 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.61 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.61 |
| ▸ | GSK3B | P49841 | 1/20 | 0.61 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.61 |
| ▸ | SLK | Q9H2G2 | 1/20 | 0.61 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.61 |
| ▸ | MAP4K5 | Q9Y4K4 | 1/20 | 0.61 |
| ▸ | KMO | O15229 | 10/20 | 0.56 |
| ▸ | AHR | P35869 | 1/20 | 0.48 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.45 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2163999 | 1.00 | DCLK1 (0.61) | DCLK1PRKD3MAP4K4EGFRPRKACA | |
| SCHEMBL2406247 | 0.84 | MAP4K4 (0.47) | DCLK1PRKD3MAP4K4EGFRPRKACA | |
| SCHEMBL27865688 | 0.84 | MAP4K4 (0.47) | DCLK1PRKD3MAP4K4EGFRPRKACA | |
| SCHEMBL17439973 | 0.84 | KMO (0.54) | DCLK1PRKD3MAP4K4EGFRPRKACA | |
| SCHEMBL9903935 | 0.79 | CYP2D6 (0.60) | DCLK1PRKD3MAP4K4EGFRPRKACA | |
| SCHEMBL14742422 | 0.79 | CAMKK2 (0.53) | DCLK1PRKD3MAP4K4EGFRPRKACA | |
| SCHEMBL4658813 | 0.78 | MAPK14 (0.58) | DCLK1PRKD3MAP4K4EGFRPRKACA | |
| SCHEMBL29450650 | 0.78 | MAPK14 (0.58) | DCLK1PRKD3MAP4K4EGFRPRKACA | |
| SCHEMBL14742209 | 0.77 | PIK3CD (0.43) | DCLK1PRKD3MAP4K4EGFRPRKACA | |
| SCHEMBL18036610 | 0.77 | KMO (0.59) | DCLK1PRKD3MAP4K4EGFRPRKACA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12036292-B2 | Heterobiaryl compounds and imaging agents for imaging huntingtin protein | CHDI FOUNDATION, INC. (US) | 2024-07-16 | — | — | US | disclosed |
| CN-116323583-A | Heterobiaryl compounds and imaging agents for imaging huntingtin | CHDI基金会股份有限公司 | 2023-06-23 | — | — | CN | disclosed |
| EP-4192819-A1 | HETEROBIARYL COMPOUNDS AND IMAGING AGENTS FOR IMAGING HUNTINGTIN PROTEIN | CHDI Foundation, Inc. (US) | 2023-06-14 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12036292-B2 | Heterobiaryl compounds and imaging agents for imaging huntingtin protein | HTT, HYPK, ATXN2L | DCLK1 1618/4885PRKD3 3489/4885MAP4K4 4058/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.