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SCHEMBL304335

SCHEMBL304335

Cn1cc(C(=O)Nc2ccccc2-c2cc(Cl)ccc2Cl)c(C(F)F)n1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ JAK2 O60674 11/20 0.49
▸ JAK1 P23458 9/20 0.49
▸ TYK2 P29597 4/20 0.49
▸ JAK3 P52333 4/20 0.49
▸ LRRK2 Q5S007 2/20 0.49
▸ NTRK1 P04629 1/20 0.47
▸ FYN P06241 1/20 0.47
▸ CYP3A4 P08684 1/20 0.47
▸ ROS1 P08922 1/20 0.47
▸ NTRK3 Q16288 1/20 0.47
▸ NTRK2 Q16620 1/20 0.47
▸ KCNMA1 Q12791 1/20 0.43
▸ POLB P06746 2/20 0.43
▸ MEN1 O00255 1/20 0.43
▸ RAB9A P51151 1/20 0.43
▸ KMT2A Q03164 1/20 0.43
▸ LMNA P02545 1/20 0.43
▸ CHRM3 P20309 3/20 0.42
▸ ATM Q13315 1/20 0.42
▸ TP53 P04637 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4109482 0.93 CHRM3 (0.49) JAK2JAK1TYK2JAK3LRRK2
SCHEMBL29419079 0.92 CHRM3 (0.47) JAK2JAK1TYK2JAK3LRRK2
SCHEMBL121453 0.92 CHRM3 (0.47) JAK2JAK1TYK2JAK3LRRK2
SCHEMBL4115329 0.92 ATM (0.42) JAK2JAK1TYK2JAK3LRRK2
SCHEMBL303173 0.91 POLB (0.46) JAK2JAK1TYK2JAK3LRRK2
SCHEMBL4453773 0.90 KCNMA1 (0.46) JAK2JAK1TYK2JAK3LRRK2
SCHEMBL4455693 0.89 POLB (0.45) JAK2JAK1TYK2JAK3LRRK2
SCHEMBL121957 0.86 TDP1 (0.53) NTRK1POLBLMNACHRM3ATM
SCHEMBL29419144 0.86 TDP1 (0.53) NTRK1POLBLMNACHRM3ATM
SCHEMBL302468 0.86 JAK2 (0.48) JAK2JAK1CYP3A4POLBMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 193 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2489262-B1 PESTICIDAL MIXTURES COMPRISING AN ANTHRANILAMIDE INSECTICIDE AND A FUNGICIDE BASF SE (DE) 2018-11-14 — — EP claimed
US-20150080215-A1 TERNARY PESTICIDAL MIXTURES BASF SE (DE) 2015-03-19 — — US claimed
US-20140179518-A1 Pesticidal Mixtures Comprising Cyanosulfoximine Compounds BASF SE (DE) 2014-06-26 — — US claimed
US-20130267414-A1 PESTICIDAL MIXTURES BASF SE (DE) 2013-10-10 — — US claimed
US-20130137571-A1 Crystalline Modification of Fipronil BASF SE (DE) 2013-05-30 — — US claimed
EP-2489264-A2 Pesticidal mixtures comprising an anthranilamide insecticide and a carboxamide fungicide BASF SE (DE) 2012-08-22 — — EP claimed
EP-2489263-A2 Pesticidal mixtures comprising an anthranilamide insecticide and a fungicide BASF SE (DE) 2012-08-22 — — EP claimed
JP-2012500824-A — — 2012-01-12 — — JP claimed
JP-2011527306-A — — 2011-10-27 — — JP claimed
EP-2378882-A2 SYNERGISTIC FUNGICIDAL MIXTURES BASF SE (DE) 2011-10-26 — — EP claimed
US-20090239748-A1 Fungicidal Mixtures Based on 2,5-Disubstituted N-Biphenylpyrazolcarboxamides BASF AKTIENGESELLSCHAFT (DE) 2009-09-24 — — US claimed
EP-2091330-A2 PESTICIDAL MIXTURES COMPRISING AN ANTHRANILAMIDE INSECTICIDE AND A FUNGICIDE BASF SE (DE) 2009-08-26 — — EP claimed
EP-2091331-A2 PESTICIDAL MIXTURES COMPRISING AN ANTHRANILAMIDE INSECTICIDE AND A FUNGICIDE BASF SE (DE) 2009-08-26 — — EP claimed
WO-2009071389-A1 FUNGICIDE MIXTURES BASF SE (DE) 2009-06-11 — — WO claimed
WO-2009071450-A1 FUNGICIDAL MIXTURE BASF SE (DE) 2009-06-11 — — WO claimed
WO-2009062905-A1 PESTICIDAL MIXTURES COMPRISING CYANOSULFOXIMINE COMPOUNDS BASF SE (DE) 2009-05-22 — — WO claimed
WO-2008148859-A2 FUNGICIDAL MIXTURES BASF SE (DE) 2008-12-11 — — WO claimed
WO-2008095913-A2 PESTICIDAL MIXTURES BASF SE (DE) 2008-08-14 — — WO claimed
WO-2008034787-A2 PESTICIDAL MIXTURES COMPRISING AN ANTHRANILAMIDE INSECTICIDE AND A FUNGICIDE BASF SE (DE) 2008-03-27 — — WO claimed
WO-2008034785-A2 PESTICIDAL MIXTURES COMPRISING AN ANTHRANILAMIDE INSECTICIDE AND A FUNGICIDE BASF SE (DE) 2008-03-27 — — WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130267414-A1 PESTICIDAL MIXTURES AADAC, CTRL, AAAS JAK2 3540/4885JAK1 3828/4885TYK2 1901/4885
US-20140179518-A1 Pesticidal Mixtures Comprising Cyanosulfoximine Compounds CPN1, SRM, STS JAK2 1531/4885JAK1 761/4885TYK2 1069/4885
US-20090239748-A1 Fungicidal Mixtures Based on 2,5-Disubstituted N-Biphenylpyrazolcarboxamides CBR3, CBR1, SNU13 JAK2 2967/4885JAK1 3230/4885TYK2 2841/4885
US-20130137571-A1 Crystalline Modification of Fipronil FIP1L1, PTMS, FIBP JAK2 4698/4885JAK1 4445/4885TYK2 4738/4885
US-20150080215-A1 TERNARY PESTICIDAL MIXTURES AADAC, AS3MT, DDT JAK2 2618/4885JAK1 2120/4885TYK2 2514/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.