SCHEMBL567351

SCHEMBL567351

Cn1cc(C(=O)Nc2ccccc2-c2ccc(Cl)c(Cl)c2)c(C(F)F)n1

nearest known ligand 0.47

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
CHRM3 P20309 9/20 0.47
ATM Q13315 1/20 0.42
LMNA P02545 2/20 0.41
NTRK1 P04629 2/20 0.41
TDP1 Q9NUW8 1/20 0.40
IRAK4 Q9NWZ3 2/20 0.40
KDM4E B2RXH2 1/20 0.39
ALDH1A1 P00352 1/20 0.39
MAPT P10636 1/20 0.39
HTT P42858 1/20 0.39
POLB P06746 1/20 0.39
JAK2 O60674 1/20 0.39
JAK1 P23458 1/20 0.39
TYK2 P29597 1/20 0.39
JAK3 P52333 1/20 0.39
LRRK2 Q5S007 1/20 0.39
SUCNR1 Q9BXA5 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4920485 0.93 CHRM3 (0.46) CHRM3ATMLMNANTRK1TDP1
SCHEMBL29445383 0.89 CHRM3 (0.51) CHRM3LMNA
SCHEMBL29437140 0.89 CHRM3 (0.42) CHRM3LMNAIRAK4
SCHEMBL304334 0.89 CHRM3 (0.42) CHRM3LMNAIRAK4
SCHEMBL29349968 0.89 CHRM3 (0.51) CHRM3LMNA
SCHEMBL68043 0.89 CHRM3 (0.51) CHRM3LMNA
SCHEMBL29419144 0.89 TDP1 (0.53) CHRM3ATMLMNANTRK1TDP1
SCHEMBL121957 0.89 TDP1 (0.53) CHRM3ATMLMNANTRK1TDP1
SCHEMBL302468 0.88 JAK2 (0.48) CHRM3ATMLMNATDP1KDM4E
SCHEMBL374079 0.88 ATM (0.43) CHRM3ATMLMNANTRK1TDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 63 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2437595-A2 USE OF SUCCINATE DEHYDROGENASE INHIBITORS FOR CONTROLLING SCLEROTINIA SSP Bayer CropScience AG (DE) 2012-04-11 EP claimed
US-20120035165-A1 Use of fungicidal compound compositions for controlling certain rust fungi BAYER CROPSCIENCE AG (DE) 2012-02-09 US claimed
EP-2330905-A1 USE OF FUNGICIDAL COMPOUND COMPOSITIONS FOR CONTROLLING CERTAIN RUST FUNGI Bayer CropScience AG (DE) 2011-06-15 EP claimed
US-20110105331-A1 Method of Plant Growth Promotion Using Amide Compounds BAYER CROPSCIENCE AG (DE) 2011-05-05 US claimed
US-20110003869-A1 Use of Succinate Dehydrogenase Inhibitors for Controlling Sclerotinia ssp. BAYER CROPSCIENCE AG (DE) 2011-01-06 US claimed
EP-2268145-A1 METHOD OF PLANT GROWTH PROMOTION USING AMIDE COMPOUNDS Bayer CropScience AG (DE) 2011-01-05 EP claimed
WO-2010139410-A2 USE OF SUCCINATE DEHYDROGENASE INHIBITORS FOR CONTROLLING SCLEROTINIA SSP. BAYER CROPSCIENCE AG (DE) 2010-12-09 WO claimed
WO-2010025832-A1 USE OF FUNGICIDAL COMPOUND COMPOSITIONS FOR CONTROLLING CERTAIN RUST FUNGI BAYER CROPSCIENCE AG (DE) 2010-03-11 WO claimed
WO-2009118161-A1 METHOD OF PLANT GROWTH PROMOTION USING AMIDE COMPOUNDS BAYER CROPSCIENCE AG (DE) 2009-10-01 WO claimed
EP-2105049-A1 Method of plant growth promotion using amide compounds Bayer CropScience AG (DE) 2009-09-30 EP claimed
US-9877482-B2 Use of succinate dehydrogenase inhibitors for controlling Sclerotinia ssp BAYER INTELLECTUAL PROPERTY GMBH (DE) 2018-01-30 US disclosed
US-9414600-B2 Active compound combinations BAYER INTELLECTUAL PROPERTY GMBH (DE) 2016-08-16 US disclosed
US-20160205932-A1 Use of Succinate Dehydrogenase Inhibitors for Controlling Sclerotinia ssp. BAYER INTELLECTUAL PROPERTY GMBH (DE) 2016-07-21 US disclosed
US-9232794-B2 Use of succinate dehydrogenase inhibitors for controlling Sclerotinia ssp BAYER INTELLECTUAL PROPERTY GMBH (DE) 2016-01-12 US disclosed
US-8754009-B2 Active compound combinations BAYER CROPSCIENCE AG (DE) 2014-06-17 US disclosed
EP-2001299-A2 FUNGICIDAL ACTIVE SUBSTANCE COMBINATIONS Bayer CropScience Aktiengesellschaft (DE) 2008-12-17 EP disclosed
US-20080108686-A1 N-(Ortho-Phenyl)-1-Methyl-3-Difluoromethylpyrazole-4-Carboxanilides And Their Use As Fungicides BASF AKTIENGESELLSCHAFT (DE) 2008-05-08 US disclosed
US-20080108686-A1 N-(Ortho-Phenyl)-1-Methyl-3-Difluoromethylpyrazole-4-Carboxanilides And Their Use As Fungicides BASF AKTIENGESELLSCHAFT (DE) 2008-05-08 US disclosed
US-20080108686-A1 N-(Ortho-Phenyl)-1-Methyl-3-Difluoromethylpyrazole-4-Carboxanilides And Their Use As Fungicides BASF AKTIENGESELLSCHAFT (DE) 2008-05-08 US disclosed
WO-2007110173-A2 FUNGICIDAL ACTIVE SUBSTANCE COMBINATIONS BAYER CROPSCIENCE AG (DE) 2007-10-04 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080108686-A1 N-(Ortho-Phenyl)-1-Methyl-3-Difluoromethylpyrazole-4-Carboxanilides And Their Use As Fungicides CBR3, DDT, CBR1 CHRM3 34/4885ATM 3853/4885LMNA 3047/4885
US-20110105331-A1 Method of Plant Growth Promotion Using Amide Compounds MYB, GHITM, MKI67 CHRM3 4166/4885ATM 3205/4885LMNA 4363/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.