Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 10/20 | 0.59 |
| ▸ | PDE3A | Q14432 | 10/20 | 0.59 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.47 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.46 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA3 | P07451 | 1/20 | 0.46 |
| ▸ | CA4 | P22748 | 1/20 | 0.46 |
| ▸ | CA6 | P23280 | 1/20 | 0.46 |
| ▸ | CA5A | P35218 | 1/20 | 0.46 |
| ▸ | CA7 | P43166 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.46 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.46 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.46 |
| ▸ | CLK1 | P49759 | 1/20 | 0.45 |
| ▸ | MGLL | Q99685 | 1/20 | 0.44 |
| ▸ | GSK3B | P49841 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4287747 | 0.88 | PDE3B (0.57) | PDE3BPDE3ACYP19A1CA12CA1 | |
| SCHEMBL27805572 | 0.81 | CA12 (0.59) | PDE3BPDE3ACA12CA1CA3 | |
| SCHEMBL17067225 | 0.80 | FGFR1 (0.59) | PDE3BPDE3ACYP19A1 | |
| SCHEMBL23207309 | 0.76 | CA9 (0.62) | PDE3BPDE3ACA12CA1CA3 | |
| SCHEMBL18000095 | 0.75 | PDE3B (0.50) | PDE3BPDE3AAAK1CLK1PDPK1 | |
| SCHEMBL4553604 | 0.75 | CDK5 (0.46) | CA12CA1CA3CA4CA6 | |
| SCHEMBL9599136 | 0.74 | ALDH1A1 (0.57) | PDE3BPDE3AGSK3BMAPK1 | |
| SCHEMBL18000228 | 0.74 | BRAF (0.58) | PDE3BPDE3ACLK1PDPK1 | |
| SCHEMBL31192609 | 0.74 | PDE3B (1.00) | PDE3BPDE3ACLK1PDPK1 | |
| SCHEMBL20494235 | 0.73 | KDM4E (0.51) | PDE3BPDE3APDPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023081212-A1 | METHODS OF USING ALK2 INHIBITORS | KEROS THERAPEUTICS, INC. (US) | 2023-05-11 | — | — | WO | disclosed |