Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.50 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.49 |
| ▸ | CFTR | P13569 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
| ▸ | AGER | Q15109 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | PARP1 | P09874 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27372816 | 1.00 | L3MBTL1 (0.53) | L3MBTL1TDP1KDM4EALDH1A1MAP2K1 | |
| SCHEMBL29416324 | 0.87 | L3MBTL1 (0.62) | L3MBTL1TDP1KDM4EALDH1A1MAP2K1 | |
| SCHEMBL69990 | 0.87 | L3MBTL1 (0.62) | L3MBTL1TDP1KDM4EALDH1A1MAP2K1 | |
| SCHEMBL13485365 | 0.86 | L3MBTL1 (0.57) | L3MBTL1TDP1KDM4EALDH1A1MAP2K1 | |
| SCHEMBL30452153 | 0.86 | L3MBTL1 (0.57) | L3MBTL1TDP1KDM4EALDH1A1MAP2K1 | |
| SCHEMBL7369472 | 0.85 | TDP1 (0.46) | L3MBTL1TDP1KDM4EALDH1A1MAP2K1 | |
| SCHEMBL2800466 | 0.84 | L3MBTL1 (0.54) | L3MBTL1TDP1KDM4EALDH1A1MAP2K1 | |
| SCHEMBL519095 | 0.84 | KDM4E (0.67) | L3MBTL1TDP1KDM4EALDH1A1MAP2K1 | |
| SCHEMBL30503698 | 0.84 | KDM4E (0.67) | L3MBTL1TDP1KDM4EALDH1A1MAP2K1 | |
| SCHEMBL9198739 | 0.83 | L3MBTL1 (0.53) | L3MBTL1TDP1KDM4EALDH1A1MAP2K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4185296-A1 | ADENOSINE A2A AND A2B RECEPTOR DUAL ANTAGONISTS FOR IMMUNO-ONCOLOGY | Merck Sharp & Dohme LLC (US) | 2023-05-31 | — | — | EP | disclosed |