Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | TTR | P02766 | 1/20 | 0.32 |
| ▸ | ALB | P02768 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31519278 | 0.81 | TRPV4 (0.42) | TRPV4 | |
| SCHEMBL22829054 | 0.81 | TRPV4 (0.42) | TRPV4MEN1KMT2A | |
| SCHEMBL29017429 | 0.81 | TRPV4 (0.42) | TRPV4 | |
| SCHEMBL29728453 | 0.78 | TRPV4 (0.52) | TRPV4 | |
| SCHEMBL809217 | 0.78 | TRPV4 (0.52) | TRPV4 | |
| SCHEMBL22496629 | 0.78 | TRPV4 (0.41) | TRPV4MEN1TTRALBKMT2A | |
| SCHEMBL9490015 | 0.78 | TRPV4 (0.56) | TRPV4 | |
| SCHEMBL31511101 | 0.77 | TRPV4 (0.38) | TRPV4 | |
| SCHEMBL17041985 | 0.75 | TRPV4 (0.37) | TRPV4 | |
| SCHEMBL8046873 | 0.74 | TRPV4 (0.48) | TRPV4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250276966-A1 | Nitrogen-Linked Benzisoxazole Sulfonamide Derivatives | PFIZER (US) | 2025-09-04 | — | — | US | disclosed |
| US-20250122183-A1 | Nitrogen-Linked Benzisoxazole Sulfonamide Derivatives | PFIZER (US) | 2025-04-17 | — | — | US | disclosed |
| WO-2025074249-A1 | NITROGEN-LINKED BENZISOXAZOLE SULFONAMIDE DERIVATIVES FOR THE TREATMENT OF CANCER | PFIZER INC. (US) | 2025-04-10 | — | — | WO | disclosed |
| CN-116262759-B | Pyrimidine tricyclic compound, and preparation method and medical application thereof | 华润医药研究院（深圳）有限公司 | 2023-12-08 | — | — | CN | disclosed |
| CN-116262759-A | Pyrimidine tricyclic compound, and preparation method and medical application thereof | 华润医药研究院（深圳）有限公司 | 2023-06-16 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250122183-A1 | Nitrogen-Linked Benzisoxazole Sulfonamide Derivatives | CCNI, MKI67, CCNA1 | TRPV4 3031/4885MEN1 1988/4885TTR 3909/4885 |
| US-20250276966-A1 | Nitrogen-Linked Benzisoxazole Sulfonamide Derivatives | CCNI, MKI67, CCNA1 | TRPV4 3093/4885MEN1 2056/4885TTR 3794/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.