Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | AR | P10275 | 2/20 | 0.48 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.42 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.42 |
| ▸ | CSF1R | P07333 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HPGDS | O60760 | 1/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.41 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | NQO1 | P15559 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21045734 | 1.00 | POLB (0.49) | POLBGAAARMAP2K1MAPK1 | |
| SCHEMBL21081168 | 0.91 | AR (0.60) | POLBGAAARMAP2K1MAPK1 | |
| SCHEMBL21045893 | 0.91 | MAP2K1 (0.49) | POLBGAAARMAP2K1MAPK1 | |
| SCHEMBL21045605 | 0.89 | L3MBTL1 (0.53) | POLBARMAP2K1MAPK1PDE10A | |
| SCHEMBL21045783 | 0.89 | CYP1A2 (0.47) | POLBGAAARPDGFRASLC22A12 | |
| SCHEMBL21045778 | 0.87 | TRPC6 (0.44) | POLBGAAARMAP2K1MAPK1 | |
| SCHEMBL21045809 | 0.86 | TRPC6 (0.44) | POLBGAAARMAP2K1MAPK1 | |
| SCHEMBL21045646 | 0.86 | RAB9A (0.45) | ARTSHRFGFR2ALDH1A1L3MBTL1 | |
| SCHEMBL21045704 | 0.86 | AR (0.42) | POLBGAAARMAP2K1PDE10A | |
| SCHEMBL30439308 | 0.86 | RAB9A (0.45) | ARTSHRFGFR2ALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111527078-B | Pyridinecarbonyl derivatives and their therapeutic use as TRPC6 inhibitors | 勃林格殷格翰国际公司 | 2023-06-02 | — | — | CN | disclosed |