Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 3/20 | 0.32 |
| ▸ | RAB9A | P51151 | 3/20 | 0.32 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.31 |
| ▸ | HPGD | P15428 | 2/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.30 |
| ▸ | MEN1 | O00255 | 2/20 | 0.30 |
| ▸ | GFER | P55789 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3047005 | 0.87 | ALDH1A1 (0.35) | ALDH1A1MAPTKDM4ETSHRSMN1; SMN2 | |
| SCHEMBL3044292 | 0.85 | FGFR1 (0.36) | ALDH1A1MAPTKDM4ETSHRSMN1; SMN2 | |
| SCHEMBL3046537 | 0.82 | FGFR1 (0.34) | ALDH1A1MAPTKDM4ETSHRSMN1; SMN2 | |
| SCHEMBL3034828 | 0.81 | GFER (0.32) | ALDH1A1MAPTKDM4ETSHRSMN1; SMN2 | |
| SCHEMBL3050515 | 0.81 | FGFR1 (0.36) | ALDH1A1MAPTKDM4ETSHRSMN1; SMN2 | |
| SCHEMBL13137244 | 0.79 | DYRK1A (0.37) | ALDH1A1MAPTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL3852750 | 0.76 | NPC1 (0.47) | ALDH1A1MAPTKDM4ETSHRSMN1; SMN2 | |
| SCHEMBL3044563 | 0.76 | EGFR (0.35) | ALDH1A1SMN1; SMN2FGFR1KMT2AGFER | |
| SCHEMBL3048638 | 0.75 | BRD4 (0.43) | ALDH1A1MAPTKDM4ETSHRNPC1 | |
| SCHEMBL3050306 | 0.74 | BRD4 (0.38) | ALDH1A1MAPTKDM4ETSHRSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100222345-A1 | NOVEL COMPOUNDS AS ANTAGONISTS OR INVERSE AGONISTS FOR OPIOID RECEPTORS | SMITHKLINE BEECHAM CORPORATION | 2010-09-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100222345-A1 | NOVEL COMPOUNDS AS ANTAGONISTS OR INVERSE AGONISTS FOR OPIOID RECEPTORS | OPRL1, OPRM1, OPRK1 | ALDH1A1 3109/4885MAPT 1626/4885KDM4E 3474/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.