Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | RXRA | P19793 | 1/20 | 0.31 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.31 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.31 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.31 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.31 |
| ▸ | SYK | P43405 | 2/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29257102 | 1.00 | PIK3CD (0.33) | PIK3CDPIK3CARXRAGRIN1GRIN2B | |
| SCHEMBL10284715 | 0.74 | MAP4K4 (0.43) | PIK3CDPIK3CARXRAGRIN1GRIN2B | |
| SCHEMBL25314029 | 0.71 | CYP11B1 (0.31) | — | |
| SCHEMBL30989714 | 0.71 | CYP11B1 (0.31) | — | |
| SCHEMBL12615927 | 0.69 | PIK3CD (0.36) | PIK3CDPIK3CARXRAGRIN1GRIN2B | |
| SCHEMBL28739251 | 0.69 | PIK3CD (0.42) | PIK3CDPIK3CAADORA2AADORA1SYK | |
| SCHEMBL2036795 | 0.69 | ADORA2A (0.45) | ADORA2AADORA1KDM4E | |
| SCHEMBL12696158 | 0.69 | PIK3CD (0.36) | PIK3CDPIK3CARXRAGRIN1GRIN2B | |
| SCHEMBL1509667 | 0.69 | PIK3CD (0.36) | PIK3CDPIK3CARXRAGRIN1GRIN2B | |
| SCHEMBL29641671 | 0.69 | PIK3CD (0.49) | PIK3CDPIK3CAADORA2AADORA1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118946360-A | Bicyclic heteroarenes and methods of use thereof | 奇尼塔公司 | 2024-11-12 | — | — | CN | disclosed |
| EP-4444317-A2 | BICYCLIC HETEROARENES AND METHODS OF THEIR USE | Kineta, Inc. (US) | 2024-10-16 | — | — | EP | disclosed |
| CN-118355004-A | Cyclopropyl- (heteroaryl) -substituted ethylsulfonyl-pyridine derivatives | 勃林格殷格翰动物保健有限公司 | 2024-07-16 | — | — | CN | disclosed |
| WO-2023107623-A2 | BICYCLIC HETEROARENES AND METHODS OF THEIR USE | Kineta, Inc. (US) | 2023-06-15 | — | — | WO | disclosed |