Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 3/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | SYK | P43405 | 9/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.48 |
| ▸ | AURKA | O14965 | 1/20 | 0.48 |
| ▸ | PRKACA | P17612 | 1/20 | 0.48 |
| ▸ | SRC | P12931 | 4/20 | 0.48 |
| ▸ | ZAP70 | P43403 | 3/20 | 0.48 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.47 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.47 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.47 |
| ▸ | CDK2 | P24941 | 3/20 | 0.45 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.45 |
| ▸ | CDK4 | P11802 | 1/20 | 0.45 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.43 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.43 |
| ▸ | CDC7 | O00311 | 2/20 | 0.43 |
| ▸ | DBF4 | Q9UBU7 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL5698717 | 0.98 | HSP90AA1 (0.96) | HSP90AA1KDM4EALDH1A1SYKRAB9A | |
| SCHEMBL8353909 | 0.82 | HSP90AA1 (0.70) | HSP90AA1SYKRAB9ASRCZAP70 | |
| SCHEMBL30511083 | 0.79 | — | — | |
| SCHEMBL14202647 | 0.77 | HSP90AA1 (0.62) | HSP90AA1SYKRAB9ASRCZAP70 | |
| SCHEMBL1536531 | 0.77 | HSP90AA1 (0.62) | HSP90AA1SYKRAB9AADORA2ASRC | |
| SCHEMBL25233346 | 0.77 | HSP90AA1 (0.62) | HSP90AA1KDM4ESYKRAB9ASRC | |
| SCHEMBL4902877 | 0.75 | RAB9A (0.61) | HSP90AA1KDM4EALDH1A1SYKRAB9A | |
| SCHEMBL929763 | 0.74 | HSP90AA1 (0.59) | HSP90AA1ALDH1A1SYKRAB9AADORA2A | |
| SCHEMBL28996170 | 0.73 | HSP90AA1 (0.58) | HSP90AA1ALDH1A1SYKRAB9AADORA2A | |
| SCHEMBL13924428 | 0.73 | SYK (0.62) | HSP90AA1SYKRAB9ASRCZAP70 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116143773-B | 2-amino-4-thiazolylpyrimidine compound and preparation method and application thereof | 中国药科大学 | 2023-07-21 | — | — | CN | claimed |
| CN-116143773-A | 2-amino-4-thiazolylpyrimidine compound and preparation method and application thereof | 中国药科大学 | 2023-05-23 | — | — | CN | claimed |
| CN-116143773-B | 2-amino-4-thiazolylpyrimidine compound and preparation method and application thereof | 中国药科大学 | 2023-07-21 | — | — | CN | disclosed |
| CN-116143773-B | 2-amino-4-thiazolylpyrimidine compound and preparation method and application thereof | 中国药科大学 | 2023-07-21 | — | — | CN | disclosed |
| CN-116143773-B | 2-amino-4-thiazolylpyrimidine compound and preparation method and application thereof | 中国药科大学 | 2023-07-21 | — | — | CN | disclosed |
| CN-116143773-A | 2-amino-4-thiazolylpyrimidine compound and preparation method and application thereof | 中国药科大学 | 2023-05-23 | — | — | CN | disclosed |
| CN-116143773-A | 2-amino-4-thiazolylpyrimidine compound and preparation method and application thereof | 中国药科大学 | 2023-05-23 | — | — | CN | disclosed |
| CN-116143773-A | 2-amino-4-thiazolylpyrimidine compound and preparation method and application thereof | 中国药科大学 | 2023-05-23 | — | — | CN | disclosed |
| CN-107118207-A | The preparation method of one class CDK inhibitor | 苏州东南药业股份有限公司 | 2017-09-01 | — | — | CN | disclosed |
| US-8541406-B2 | Thiadiazole derivatives for the treatment of neurodegenerative diseases | NV REMYND (BE) | 2013-09-24 | — | — | US | disclosed |
| US-20100261707-A9 | THIADIAZOLE DERIVATIVES FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | NV REMYND (BE) | 2010-10-14 | — | — | US | disclosed |
| US-20090233911-A2 | THIADIAZOLE DERIVATIVES FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | NV REMYND (BE) | 2009-09-17 | — | — | US | disclosed |
| US-20090054410-A1 | THIADIAZOLE DERIVATIVES FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | NV REMYND (BE) | 2009-02-26 | — | — | US | disclosed |
| US-7488727-B2 | Thiazole compounds useful as inhibitors of protein kinase | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2009-02-10 | — | — | US | disclosed |
| US-7488727-B2 | Thiazole compounds useful as inhibitors of protein kinase | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2009-02-10 | — | — | US | disclosed |
| US-20070249645-A1 | THIAZOLE COMPOUNDS USEFUL AS INHIBITORS OF PROTEIN KINASE | VERTEX PHARMACEUTICALS INCORPORATED | 2007-10-25 | — | — | US | disclosed |
| US-20070249645-A1 | THIAZOLE COMPOUNDS USEFUL AS INHIBITORS OF PROTEIN KINASE | VERTEX PHARMACEUTICALS INCORPORATED | 2007-10-25 | — | — | US | disclosed |
| US-7256190-B2 | Thiazole compounds useful as inhibitors of protein kinase | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-08-14 | — | — | US | disclosed |
| US-7256190-B2 | Thiazole compounds useful as inhibitors of protein kinase | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-08-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090233911-A2 | THIADIAZOLE DERIVATIVES FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | SNCA, HTT, PARK7 | HSP90AA1 154/4885KDM4E 4164/4885ALDH1A1 1930/4885 |
| US-20100261707-A9 | THIADIAZOLE DERIVATIVES FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | SNCA, HTT, PARK7 | HSP90AA1 154/4885KDM4E 4164/4885ALDH1A1 1930/4885 |
| US-20070249645-A1 | THIAZOLE COMPOUNDS USEFUL AS INHIBITORS OF PROTEIN KINASE | BTK, AURKC, GSK3B | HSP90AA1 1568/4885KDM4E 1294/4885ALDH1A1 3785/4885 |
| US-20090054410-A1 | THIADIAZOLE DERIVATIVES FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | SNCA, HTT, PARK7 | HSP90AA1 154/4885KDM4E 4164/4885ALDH1A1 1930/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.