Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 2/20 | 0.44 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.44 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.44 |
| ▸ | SNCA | P37840 | 7/20 | 0.64 |
| ▸ | NOX1 | Q9Y5S8 | 9/20 | 0.46 |
| ▸ | GAA | P10253 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | BCHE | P06276 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.44 |
| ▸ | MAOA | P21397 | 1/20 | 0.44 |
| ▸ | CNR1 | P21554 | 1/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL20495634 | 1.00 | SNCA (0.64) | SNCANOX1GAAMAPTMEN1 | |
| SCHEMBL29637682 | 0.98 | SNCA (0.66) | SNCANOX1GAAMAPTMEN1 | |
| SCHEMBL2582828 | 0.98 | SNCA (0.66) | SNCANOX1GAAMAPTMEN1 | |
| SCHEMBL30065446 | 0.90 | SNCA (0.58) | SNCANOX1GAAMAPTMEN1 | |
| SCHEMBL205578 | 0.90 | SNCA (0.58) | SNCANOX1GAAMAPTMEN1 | |
| SCHEMBL4708193 | 0.88 | SNCA (0.57) | SNCANOX1GAAMAPTMEN1 | |
| SCHEMBL30769565 | 0.88 | NOX1 (0.65) | SNCANOX1GAAMAPTMEN1 | |
| SCHEMBL239782 | 0.88 | NOX1 (0.65) | SNCANOX1GAAMAPTMEN1 | |
| SCHEMBL9391898 | 0.86 | SNCA (0.55) | SNCANOX1GAAMAPTMEN1 | |
| SCHEMBL19744465 | 0.83 | NOX1 (0.57) | SNCANOX1GAAMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110418784-B | Process for preparing 3, 7-bis- (dimethylamino) -phenothiazin-5-ium chloride or bromide | 米克罗化学有限责任公司 | 2023-06-09 | — | — | CN | disclosed |