SCHEMBL30451384

SCHEMBL30451384

O=C1CCOc2ccc(Cl)cc21

nearest known ligand 0.50

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
MAOB P27338 6/20 0.50
VHL P40337 1/20 0.50
ELOC Q15369 1/20 0.50
ELOB Q15370 1/20 0.50
MAOA P21397 1/20 0.50
CTSL P07711 1/20 0.48
NPSR1 Q6W5P4 1/20 0.48
GRM5 P41594 2/20 0.47
CYP19A1 P11511 1/20 0.45
NOTUM Q6P988 1/20 0.42
MAPT P10636 1/20 0.42
PKM P14618 1/20 0.42
PIK3CA P42336 1/20 0.42
PIK3CB P42338 1/20 0.42
PIK3CG P48736 1/20 0.42
AR P10275 1/20 0.41
S100A4 P26447 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL69670 1.00 MAOB (0.50) MAOBVHLELOCELOBMAOA
SCHEMBL1181902 0.89 CTSL (0.46) MAOBVHLELOCELOBMAOA
SCHEMBL4726346 0.85 MAOB (0.64) MAOBVHLELOCELOBMAOA
Hydrochloric Acid SCHEMBL27916520 0.84 MAOB (0.62) MAOBVHLELOCELOBMAOA
SCHEMBL28033205 0.82 MAOB (0.49) MAOBMAOAGRM5
SCHEMBL20554210 0.82 MAOB (0.55) MAOBMAOANPSR1GRM5MAPT
SCHEMBL69423 0.81 MAOB (0.55) MAOBVHLELOCELOBCYP19A1
SCHEMBL67612 0.78 MAOB (0.50) MAOBMAOANPSR1GRM5AR
SCHEMBL16789730 0.78 MAOB (0.50) MAOBMAOANPSR1GRM5
SCHEMBL4476431 0.78 MAOB (0.50) MAOBMAOACTSLNPSR1GRM5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116947903-A Inhibitors of complement factors and uses thereof 安尼艾克松股份有限公司 2023-10-27 CN disclosed
CN-116261564-A Inhibitors of complement factors and uses thereof 安尼艾克松股份有限公司 2023-06-13 CN disclosed