Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RNASEH1 | O60930 | 1/20 | 0.45 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.44 |
| ▸ | HSP90B1 | P14625 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.42 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.39 |
| ▸ | CES2 | O00748 | 1/20 | 0.39 |
| ▸ | FPR1 | P21462 | 1/20 | 0.39 |
| ▸ | CASP3 | P42574 | 1/20 | 0.39 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.39 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.39 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24257546 | 1.00 | RNASEH1 (0.45) | RNASEH1HSP90AA1HSP90B1ALDH1A1SMN1; SMN2 | |
| SCHEMBL30453338 | 0.85 | EGLN1 (0.44) | RNASEH1ALDH1A1EGLN1CNR2GPR55 | |
| SCHEMBL24257783 | 0.85 | EGLN1 (0.44) | RNASEH1ALDH1A1EGLN1CNR2GPR55 | |
| SCHEMBL24257549 | 0.82 | EGLN1 (0.51) | ALDH1A1SMN1; SMN2HPGDEGLN1CNR2 | |
| SCHEMBL24257458 | 0.81 | EGLN1 (0.67) | ALDH1A1EGLN1 | |
| SCHEMBL30452505 | 0.79 | EGLN1 (0.51) | ALDH1A1SMN1; SMN2HPGDEGLN1 | |
| SCHEMBL2146828 | 0.78 | MAPT (0.44) | RNASEH1HSP90AA1HSP90B1ALDH1A1SMN1; SMN2 | |
| Formic Acid SCHEMBL30453300 | 0.77 | EGLN1 (0.62) | ALDH1A1EGLN1 | |
| SCHEMBL22290167 | 0.76 | NPSR1 (0.44) | HSP90AA1HSP90B1ALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL754010 | 0.74 | NPSR1 (0.47) | RNASEH1ALDH1A1SMN1; SMN2HPGDNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116670131-A | PHD inhibitor compounds, compositions, and methods of use | 阿克比治疗有限公司 | 2023-08-29 | — | — | CN | disclosed |
| EP-4196466-A1 | PHD INHIBITOR COMPOUNDS, COMPOSITIONS, AND METHODS OF USE | Akebia Therapeutics Inc. (US) | 2023-06-21 | — | — | EP | disclosed |